Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정재윤 | - |
dc.date.accessioned | 2019-11-24T16:54:01Z | - |
dc.date.available | 2019-11-24T16:54:01Z | - |
dc.date.issued | 2017-04 | - |
dc.identifier.citation | POLYMERS FOR ADVANCED TECHNOLOGIES, v. 28, no. 4, page. 443-448 | en_US |
dc.identifier.issn | 1042-7147 | - |
dc.identifier.issn | 1099-1581 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1002/pat.3904 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/113742 | - |
dc.description.abstract | Cancer-selective internalization has a great potential for reducing the side effect of photodynamic therapy. Recently, various cancer-targeted delivery carriers have provided enhanced cancer targeting efficiency. Despite significant advancements in cancer-targeted carriers, side effects are still present because of non-selective cellular uptake that occurs in the heterogeneous cancer environment. In this paper, we designed two types of cancer-selectable two arm hydrophilic photosensitizer (CTAHP2K and CTAHP4K) with silicon-tetrapyrazinoporphyrazines (ST), polyethylene glycol and the cancer-specific ligand for cancer-selective theranostics. The synthesized CTAHP4K exhibits a folate receptor-mediated cancer-selective cellular uptake and induces cancer-selective death. The folate receptor-mediated cancer-selective internalization of CTAHP4K was confirmed by competitive interaction with vitamin B in MDA-MB-231 human breast carcinoma. The cancer-selective cytotoxicity of CTAHP4K was confirmed using a 670-nm laser to irradiate Chang Liver cells and MDA-MB-231 cells. Copyright (c) 2016 John Wiley & Sons, Ltd. | en_US |
dc.description.sponsorship | This work was supported by the Strategic core materials technology development (10047756, Development of tetra-pyrrole type for color, light-emitting, detecting device) funded by the Ministry of Trade, Industry & Energy (MI, Korea) and research funds from the Catholic University of Korea (Research Fund 2016). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WILEY | en_US |
dc.subject | cancer selective | en_US |
dc.subject | photodynamic therapy | en_US |
dc.subject | hydrophilic photosensitizer | en_US |
dc.subject | vitamin B | en_US |
dc.subject | theranostic | en_US |
dc.title | Two arms hydrophilic photosensitizer conjugates with vitamin B for cancer-selective photodynamic therapy | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 28 | - |
dc.identifier.doi | 10.1002/pat.3904 | - |
dc.relation.page | 443-448 | - |
dc.relation.journal | POLYMERS FOR ADVANCED TECHNOLOGIES | - |
dc.contributor.googleauthor | Kim, Kyoung Sub | - |
dc.contributor.googleauthor | Song, Cheol Jun | - |
dc.contributor.googleauthor | Jaung, Jae Yun | - |
dc.contributor.googleauthor | Na, Kun | - |
dc.relation.code | 2017001352 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF ORGANIC AND NANO ENGINEERING | - |
dc.identifier.pid | jjy1004 | - |
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