Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최윤영 | - |
dc.date.accessioned | 2019-11-22T06:40:40Z | - |
dc.date.available | 2019-11-22T06:40:40Z | - |
dc.date.issued | 2017-04 | - |
dc.identifier.citation | REPRODUCTIVE TOXICOLOGY, v. 69, page. 43-52 | en_US |
dc.identifier.issn | 0890-6238 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0890623817300217?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/113604 | - |
dc.description.abstract | Chronic caffeine consumption exerts a negligible effect on the reproductive organs of normal adult females, but it is not known whether this is also true for children and adolescents. Here, we investigated the effects of high caffeine exposure on sexual maturation and ovarian estradiol production in immature female rats. Immature female SD rats were divided into controls and caffeine groups fed 120 and 180 mg/kg/day for 4 or 8 weeks. There was a significant delay in vaginal opening in the caffeine fed groups. In addition, serum estradiol levels were elevated in the caffeine-fed animals after 2 and 4 weeks of exposure. Estradiol secretion as well as aromatase expression also increased significantly in the ovarian cells in response to caffeine. These results demonstrate that peripubertal exposure to high caffeine increases estradiol production in the ovary; this may disturb the coordinated regulation of the hypothalamo-pituitary-ovarian axis, thereby interfering with sexual maturation. (C) 2017 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | YK, HC, and JB participated in the experiments, data collection and analysis; YYC, participated in the experiments; JR, contributed to the design of the study, data analysis, supervision and development of the manuscript. JR takes responsibility for the integrity of the data analysis. All authors read and approved the final manuscript. This study was supported by the Ministry of Education and Science (NRF-2014R1A1A2053601). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.subject | Caffeine | en_US |
dc.subject | Puberty | en_US |
dc.subject | Ovary | en_US |
dc.subject | Estrogen | en_US |
dc.subject | Aromatase | en_US |
dc.subject | Uterus | en_US |
dc.subject | Estrogen receptor | en_US |
dc.subject | Rat | en_US |
dc.title | Peri-pubertal high caffeine exposure increases ovarian estradiol production in immature rats | en_US |
dc.type | Article | en_US |
dc.relation.volume | 69 | - |
dc.identifier.doi | 10.1016/j.reprotox.2017.01.007 | - |
dc.relation.page | 43-52 | - |
dc.relation.journal | REPRODUCTIVE TOXICOLOGY | - |
dc.contributor.googleauthor | Kwak, Yoojin | - |
dc.contributor.googleauthor | Choi, Hyeonhae | - |
dc.contributor.googleauthor | Bae, Jaeman | - |
dc.contributor.googleauthor | Choi, Yun-Young | - |
dc.contributor.googleauthor | Roh, Jaesook | - |
dc.relation.code | 2017000440 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | yychoi | - |
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