Evaluation of disease chronicity by bone marrow fat fraction using sacroiliac joint magnetic resonance imaging in patients with spondyloarthritis: A retrospective study
- Title
- Evaluation of disease chronicity by bone marrow fat fraction using sacroiliac joint magnetic resonance imaging in patients with spondyloarthritis: A retrospective study
- Author
- 김태환
- Keywords
- fat fraction; magnetic resonance imaging; modified Dixon; sacroiliac joint; spondyloarthritis
- Issue Date
- 2019-04
- Publisher
- WILEY
- Citation
- INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v. 22, NO 4, Page. 734-741
- Abstract
- Aim This study investigated the use of fat fraction (FF) measurements in the sacroiliac (SI) joint to determine radiologic progression in patients with spondyloarthritis (SpA).
Method A total of 138 patients who underwent pelvic magnetic resonance imaging (MRI) between September 2014 and March 2015 were retrospectively evaluated. The FF based upon fat deposition (%) using fat signaling on T1 and T2 weighted images in the sacroiliac joint was quantified using a 6-echo variant of the modified Dixon technique. We defined the normal bone marrow as normal FF, bone marrow edema as active inflammatory FF, and fat metaplasia as post-inflammatory FF.
Results The mean FF of normal marrow was 52.0%10.4% and 50.5%+/- 10.1% in the left and right SI joints, respectively. The mean FF of post-inflammatory fat deposition was 81.9%+/- 9.7% and 82.3%+/- 9.6% in the left and right SI joints, respectively. The mean FF of active inflammatory fat deposition was 15.8%+/- 5.9% and 13.5%+/- 6.7% in the left and right SI joints, respectively. In multiple linear regression, post-inflammatory FF was found to be significantly associated with radiologic progression, such as symptom duration, SI joint grade, and modified Stoke Ankylosing Spondylitis Spine Score.
Conclusion Post-inflammatory FF indicates the chronicity of SpA. Evaluating FF using MRI in the SI joint will help to determine radiologic progression.
- URI
- https://onlinelibrary.wiley.com/doi/full/10.1111/1756-185X.13485https://repository.hanyang.ac.kr/handle/20.500.11754/110945
- ISSN
- 1756-1841; 1756-185X
- DOI
- 10.1111/1756-185X.13485
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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