Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2019-08-08T05:30:11Z | - |
dc.date.available | 2019-08-08T05:30:11Z | - |
dc.date.issued | 2006-07 | - |
dc.identifier.citation | RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 20, No. 13, Page. 1981-1988 | en_US |
dc.identifier.issn | 0951-4198 | - |
dc.identifier.issn | 1097-0231 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/full/10.1002/rcm.2549 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/108355 | - |
dc.description.abstract | The metabolism and excretion of 2-methylaminoethoxycarbonyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2"-carboxylic acid (DDB-S) were investigated in both rats and humans using liquid chromatography/electrospray ion trap mass spectrometry (LC/ESI-MS/MS). In rats, DDB-S was rapidly eliminated from the body after a single 50mg/kg intravenous injection, with urine being a major excretion route. DDB-S was metabolically stable; approximately 96% of the administered dose was recovered in the form of the parent compound. Nevertheless, 12 metabolites were detected in the urine and feces collected from DDB-S-treated rats. The structural characterizations of the metabolites were elucidated from the MSn spectral analysis. Because DDB-S has a pseudo-symmetrical methylenedioxy biphenyl structure, regioselective deuterium-substituted DDB-S (d(5)-DDB-S) was used to assign the metabolic modification. The major metabolic pathways of DDB-S were identified as demethylenation of the methylenedioxy moiety, O-demethylation of the methoxy moiety and glucuronidation. In addition, N-demethylation of the methylaminoethyl group was also detected as a minor reaction. Copyright (c) 2006 John Wiley & Sons, Ltd. | en_US |
dc.description.sponsorship | This work was supported by intra‐mural grants from the Korea Institute of Science and Technology. | en_US |
dc.language.iso | ko_KR | en_US |
dc.publisher | JOHN WILEY & SONS LTD | en_US |
dc.title | The metabolism and excretion of 2‐methylaminoethoxycarbonyl‐4,4′‐dimethoxy‐5,6,5′,6′‐dimethylenedioxybiphenyl‐2′‐carboxylic acid (DDB‐S) in rats and human | en_US |
dc.type | Article | en_US |
dc.relation.volume | 20 | - |
dc.identifier.doi | 10.1002/rcm.2549 | - |
dc.relation.page | 1981-1988 | - |
dc.relation.journal | RAPID COMMUNICATIONS IN MASS SPECTROMETRY | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.contributor.googleauthor | Son, Junghyun | - |
dc.contributor.googleauthor | Lee, Jaeick | - |
dc.contributor.googleauthor | Kim, Nam Sun | - |
dc.contributor.googleauthor | Shin, Myungyoup | - |
dc.contributor.googleauthor | Kang, Min-Jung | - |
dc.contributor.googleauthor | Kim, Dong-Hyun | - |
dc.relation.code | 2009208140 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
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