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The cytotoxic saponin from heat-processed Achyranthes fauriei roots

Title
The cytotoxic saponin from heat-processed Achyranthes fauriei roots
Author
유혜현
Keywords
Achyranthes fauriei; Amaranthaceae; cytotoxic activity; bioassay-linked HPLC-ELSD; chikusetsusaponin IVa
Issue Date
2006-05
Publisher
PHARMACEUTICAL SOC JAPAN
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v. 29, No. 5, Page. 1053-1055
Abstract
An extract of heat-processed Achyranthes fauriei roots showed more potent cytotoxic activity against human hepatoma SK-Hep-1 cells than that of the crude plant. Employing a bioassay-linked HPLC-ELSD (high performance liquid chromatography-evaporative light scattering detector) method, followed by silica gel column chromatography, a cytotoxic triterpenoid saponin, chikusetsusaponin IVa was isolated. It is contributive to the increased cytotoxic activity of the heat-processed. The amount of chikusetsusaponin IVa from the roots of Achyranthes fauriei was significantly increased after heat-processing.
URI
https://www.jstage.jst.go.jp/article/bpb/29/5/29_5_1053/_article/-char/ja/http://repository.hanyang.ac.kr/handle/20.500.11754/107980
ISSN
0918-6158
DOI
10.1248/bpb.29.1053
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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