27 0

An injected bacterial effector targets chromatin access for transcription factor NF-kappa B to alter transcription of host genes involved in immune responses

Title
An injected bacterial effector targets chromatin access for transcription factor NF-kappa B to alter transcription of host genes involved in immune responses
Author
김동욱
Keywords
SHIGELLA-FLEXNERI; MAP KINASE; HISTONE H3; EPITHELIAL-CELLS; ACTIVATION; EXPRESSION; PHOSPHOACETYLATION; PHOSPHORYLATION; RECRUITMENT; SECRETION
Issue Date
2007-01
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE IMMUNOLOGY, v. 8, No. 1, Page. 47-56
Abstract
Phosphorylation of histone H3 at Ser10 increases chromatin accessibility to transcription factor NF-kappa B on a subset of genes involved in immune responses. Here we report that a bacterial pathogen abrogated phosphorylation of histone H3 to 'shape' the transcriptional responses of infected host cells. We identify the Shigella flexneri protein effector OspF as a dually specific phosphatase that dephosphorylated mitogen-activated protein kinases in the nucleus, thus preventing histone H3 phosphorylation at Ser10 in a gene-specific way. That activity of OspF enabled shigella to block the activation of a subset of NF-kappa B-responsive genes, leading to compromised recruitment of polymorphonuclear leukocytes to infected tissues. S. flexneri has thus evolved the capacity to precisely modulate host cell epigenetic 'information' as a strategy for repressing innate immunity.
URI
https://www.nature.com/articles/ni1423http://repository.hanyang.ac.kr/handle/20.500.11754/106231
ISSN
1529-2908; 1529-2916
DOI
10.1038/ni1423
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE