An injected bacterial effector targets chromatin access for transcription factor NF-kappa B to alter transcription of host genes involved in immune responses
- Title
- An injected bacterial effector targets chromatin access for transcription factor NF-kappa B to alter transcription of host genes involved in immune responses
- Author
- 김동욱
- Keywords
- SHIGELLA-FLEXNERI; MAP KINASE; HISTONE H3; EPITHELIAL-CELLS; ACTIVATION; EXPRESSION; PHOSPHOACETYLATION; PHOSPHORYLATION; RECRUITMENT; SECRETION
- Issue Date
- 2007-01
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE IMMUNOLOGY, v. 8, No. 1, Page. 47-56
- Abstract
- Phosphorylation of histone H3 at Ser10 increases chromatin accessibility to transcription factor NF-kappa B on a subset of genes involved in immune responses. Here we report that a bacterial pathogen abrogated phosphorylation of histone H3 to 'shape' the transcriptional responses of infected host cells. We identify the Shigella flexneri protein effector OspF as a dually specific phosphatase that dephosphorylated mitogen-activated protein kinases in the nucleus, thus preventing histone H3 phosphorylation at Ser10 in a gene-specific way. That activity of OspF enabled shigella to block the activation of a subset of NF-kappa B-responsive genes, leading to compromised recruitment of polymorphonuclear leukocytes to infected tissues. S. flexneri has thus evolved the capacity to precisely modulate host cell epigenetic 'information' as a strategy for repressing innate immunity.
- URI
- https://www.nature.com/articles/ni1423https://repository.hanyang.ac.kr/handle/20.500.11754/106231
- ISSN
- 1529-2908; 1529-2916
- DOI
- 10.1038/ni1423
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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