Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동욱 | - |
dc.date.accessioned | 2019-06-03T07:48:19Z | - |
dc.date.available | 2019-06-03T07:48:19Z | - |
dc.date.issued | 2007-01 | - |
dc.identifier.citation | NATURE IMMUNOLOGY, v. 8, No. 1, Page. 47-56 | en_US |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.issn | 1529-2916 | - |
dc.identifier.uri | https://www.nature.com/articles/ni1423 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/106231 | - |
dc.description.abstract | Phosphorylation of histone H3 at Ser10 increases chromatin accessibility to transcription factor NF-kappa B on a subset of genes involved in immune responses. Here we report that a bacterial pathogen abrogated phosphorylation of histone H3 to 'shape' the transcriptional responses of infected host cells. We identify the Shigella flexneri protein effector OspF as a dually specific phosphatase that dephosphorylated mitogen-activated protein kinases in the nucleus, thus preventing histone H3 phosphorylation at Ser10 in a gene-specific way. That activity of OspF enabled shigella to block the activation of a subset of NF-kappa B-responsive genes, leading to compromised recruitment of polymorphonuclear leukocytes to infected tissues. S. flexneri has thus evolved the capacity to precisely modulate host cell epigenetic 'information' as a strategy for repressing innate immunity. | en_US |
dc.description.sponsorship | We thank R. Weil and S. Memet for critical reading of the manuscript; J. Rohde, C. Rougeot, L. Touqui and A. Garcia for discussions; and B. Regnault and J. Bergounioux for technical assistance. The pGEX 2T plasmid containing human Erk2 was a gift from C. Marshall (Institute of Cancer Research); antibody to histone H3 methylated at Lys9 and phosphorylated at Ser10 was a gift from C. Muchardt (Institut Pasteur); and anti-p50 and anti-p65 were gifts from R. Weil (Institut Pasteur). Supported by the Howard Hughes Medical Institute (P.J.S.). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | SHIGELLA-FLEXNERI | en_US |
dc.subject | MAP KINASE | en_US |
dc.subject | HISTONE H3 | en_US |
dc.subject | EPITHELIAL-CELLS | en_US |
dc.subject | ACTIVATION | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | PHOSPHOACETYLATION | en_US |
dc.subject | PHOSPHORYLATION | en_US |
dc.subject | RECRUITMENT | en_US |
dc.subject | SECRETION | en_US |
dc.title | An injected bacterial effector targets chromatin access for transcription factor NF-kappa B to alter transcription of host genes involved in immune responses | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.1038/ni1423 | - |
dc.relation.page | 47-56 | - |
dc.relation.journal | NATURE IMMUNOLOGY | - |
dc.contributor.googleauthor | Arbibe, Laurence | - |
dc.contributor.googleauthor | Kim, Dong Wook | - |
dc.contributor.googleauthor | Batsche, Eric | - |
dc.contributor.googleauthor | Pedron, Thierry | - |
dc.contributor.googleauthor | Mateescu, Bogdan | - |
dc.contributor.googleauthor | Muchardt, Christian | - |
dc.contributor.googleauthor | Parsot, Claude | - |
dc.contributor.googleauthor | Sansonetti, Philippe J. | - |
dc.relation.code | 2007206937 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | dongwook | - |
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