Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기현 | - |
dc.date.accessioned | 2019-05-27T07:52:57Z | - |
dc.date.available | 2019-05-27T07:52:57Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | TRENDS IN BIOCHEMICAL SCIENCES, v. 44, NO 3, Page. 190-213 | en_US |
dc.identifier.issn | 0968-0004 | - |
dc.identifier.issn | 1362-4326 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0968000418302287?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/106033 | - |
dc.description.abstract | DNAzymes have been widely explored owing to their excellent catalytic activity in a broad range of applications, notably in sensing and biomedical devices. These newly discovered applications have built high hopes for designing novel catalytic DNAzymes. However, the selection of efficient DNAzymes is a challenging process but one that is of crucial importance. Initially, systemic evolution of ligands by exponential enrichment (SELEX) was a labor-intensive and time-consuming process, but recent advances have accelerated the automated generation of DNAzyme molecules. This review summarizes recent advances in SELEX that improve the affinity and specificity of DNAzymes. The thriving generation of new DNAzymes is expected to open the door to several healthcare applications. Therefore, a significant portion of this review is dedicated to various biological applications of DNAzymes, such as sensing, therapeutics, and nanodevices. In addition, discussion is further extended to the barriers encountered for the real-life application of these DNAzymes to provide a foundation for future research. | en_US |
dc.description.sponsorship | S.K. thanks the Department of Science and Technology (DST), the Government of India, the University of Nebraska (UNL) at Lincoln, the Daugherty Water for Food Institute (DWFI), and the Indo-US Science and Technology Forum (IUSSTF) for financial support through the Water Advanced Research and Innovation (WARI) Program (award IUSSTF/WARI/2018/F-029-2018, 03-01-2018) as well as the Department of Biotechnology (DBT), Government of India (award BT/PR18868/BCE/8/1370/2016, 31-01-2018), and DST-PURSE (Promotion of University Research and Scientific Excellence) via GJUS& T, Hisar, under PURSE program SR/PURSE Phase 2/40(G). S.J. thanks the University Grants Commission (UGC), India, for providing financial assistance in the form of a Junior Research Fellowship [award F.16-6 (Dec. 2016)/2017 (NET), 12-09-2017]. K.H.K. acknowledges grant support from the National Research Foundation of Korea (NRF) funded by the MSIP (Ministry of Science, ICT, and Future Planning), Government of Korea (grant 2016R1E1A1A01940995) as well as the support made by the R&D Center for Green Patrol Technologies through the R&D for Global Top Environmental Technologies funded by the Ministry of Environment (MOE 2018001850001). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE LONDON | en_US |
dc.subject | INHIBIT CELL-PROLIFERATION | en_US |
dc.subject | HIGHLY SENSITIVE DETECTION | en_US |
dc.subject | DNA-CLEAVING DNAZYME | en_US |
dc.subject | IN-VITRO SELECTION | en_US |
dc.subject | APTAMER SELECTION | en_US |
dc.subject | RNA APTAMERS | en_US |
dc.subject | CAPILLARY-ELECTROPHORESIS | en_US |
dc.subject | ELECTROCHEMICAL SENSORS | en_US |
dc.subject | ADENOSINE-TRIPHOSPHATE | en_US |
dc.subject | CARBON NANOTUBES | en_US |
dc.title | Advanced selection methodologies for DNAzymes in sensing and healthcare applications. | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 44 | - |
dc.identifier.doi | 10.1016/j.tibs.2018.11.001 | - |
dc.relation.page | 190-213 | - |
dc.relation.journal | TRENDS IN BIOCHEMICAL SCIENCES | - |
dc.contributor.googleauthor | Kumar, Sandeep | - |
dc.contributor.googleauthor | Jain, Shikha | - |
dc.contributor.googleauthor | Dilbaghi, Neeraj | - |
dc.contributor.googleauthor | Ahluwalia, Amrik Singh | - |
dc.contributor.googleauthor | Hassan, Ashraf Aly | - |
dc.contributor.googleauthor | Kim, Ki-Hyun | - |
dc.relation.code | 2019003314 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF CIVIL AND ENVIRONMENTAL ENGINEERING | - |
dc.identifier.pid | kkim61 | - |
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