Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손장원 | - |
dc.date.accessioned | 2019-05-23T07:16:30Z | - |
dc.date.available | 2019-05-23T07:16:30Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | Allergy asthma & respiratory disease 제5권 제1호2017 41 - 46 (6 pages) | en_US |
dc.identifier.issn | 2288-0402 | - |
dc.identifier.issn | 2288-0410 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4168/aard.2017.5.1.41 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/105946 | - |
dc.description.abstract | Purpose: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of med ications. Previously, IL-10 gene polymorphism has been reported to be associated with diclofenac-induced hepatitis. In this study, we aimed to investigate the associations between genetic polymorphisms of immune-regulating cytokines (IL-10 and TGF-β1) with antituberculosis drugs (ATD)-induced liver injury. Methods: We enrolled 80 patients with ATD-induced liver injury and 238 ATD-tolerant controls. Two single nucleotide polymor phisms (SNP) of IL-10 (-1082A>G, rs1800896; -819T>C, rs1800871) and one promoter SNP of TGF-β1 gene (-509C>T, rs1800469) were genotyped in both groups. Genotype frequencies of these SNPs were compared between case and control groups. Results: In 2 promoter SNPs of IL-10 gene, there was no significant difference of genotype frequencies between patients with ATD-induced liver injury and controls. In addition, the genotype frequency of TGF-β1 -509C>T SNP in ATD-induced liver injury patients were not different from those of controls. Conclusion: In conclusion, there was no significant association between IL-10 and TGF-β1 gene polymorphisms and ATD-induced liver injury. These findings suggest that IL-10 and TGF-β1 do not play important role in the development of ATD-induced liver injury. (Allergy Asthma Respir Dis 2017:5:41-46) | en_US |
dc.language.iso | ko_KR | en_US |
dc.publisher | 대한천식알레르기학회(구 대한알레르기학회) | en_US |
dc.subject | 항결핵제 | en_US |
dc.subject | 약물 유발 간 손상 | en_US |
dc.subject | 인터루킨 -10 | en_US |
dc.subject | 형질 전환 성장 인자 β1 | en_US |
dc.subject | 유전 적 다형성 | en_US |
dc.subject | Antitubercular agents | en_US |
dc.subject | Drug-induced liver injury | en_US |
dc.subject | Interleukin-10 | en_US |
dc.subject | Transforming growth factor beta1 | en_US |
dc.subject | Genetic polymor phism | en_US |
dc.title | 항결핵제유발 간 손상에서 인터루킨-10과 전환성장인자- 베타1 유전다형태 | en_US |
dc.title.alternative | Genetic polymorphisms of interleukin-10 and transforming growth factor-β1 and antituberculosis drugs-induced liver injury | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 5 | - |
dc.identifier.doi | https://doi.org/10.4168/aard.2017.5.1.41 | - |
dc.relation.page | 41-46 | - |
dc.relation.journal | Allergy Asthma & Respiratory Diseases | - |
dc.contributor.googleauthor | 정소담 | - |
dc.contributor.googleauthor | 김상훈 | - |
dc.contributor.googleauthor | 손장원 | - |
dc.contributor.googleauthor | 윤호주 | - |
dc.contributor.googleauthor | 신동호 | - |
dc.contributor.googleauthor | 지영구 | - |
dc.contributor.googleauthor | 김상헌 | - |
dc.contributor.googleauthor | Jung, Sodam | - |
dc.contributor.googleauthor | Kim, Sang-Hoon | - |
dc.contributor.googleauthor | Sohn, Jang Won | - |
dc.contributor.googleauthor | Yoon, Ho Joo | - |
dc.contributor.googleauthor | Shin, Dong Ho | - |
dc.contributor.googleauthor | Jee, Young-Koo | - |
dc.contributor.googleauthor | Kim, Sang-Heon | - |
dc.relation.code | 2017019943 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jwsohn | - |
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