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Vibrating droplet generation to assemble zwitterion-coated gold-graphene oxide stealth nanovesicles for effective pancreatic cancer chemo-phototherapy

Title
Vibrating droplet generation to assemble zwitterion-coated gold-graphene oxide stealth nanovesicles for effective pancreatic cancer chemo-phototherapy
Author
최한곤
Keywords
LIQUID-CRYSTALLINE NANOPARTICLES; DRUG-DELIVERY-SYSTEMS; IN-VIVO; BREAST-CANCER; CELLULAR UPTAKE; THERAPY; PH; DOXORUBICIN; RELEASE; NANOMEDICINE
Issue Date
2018-02
Publisher
ROYAL SOC CHEMISTRY
Citation
NANOSCALE, v. 10, No. 4, Page. 1742-1749
Abstract
A vibrating nozzle approach was used to produce uniform (similar to 2 mu m) hybrid droplets containing gold-graphene oxide (Au-GO), doxorubicin (DOX), and zwitterionic chitosan (ZC) for assembly of Au-GO@ZC-DOX stealth nanovesicles (NVs) via a single-pass diffusion drying process without any hydrothermal reactions, separations, or purifications. NVs were prepared with a lateral dimension of similar to 53.0 nm, a pH-triggered high DOX release profile, and strong photothermal effects. Macrophage opsonization was prevented, resulting in anti-cancer and anti-migration effects, with high intracellular uptake in PANC-1 and MIA PaCa-2 cells. PANC-1 tumor uptake was greater for NVs having the ZC configuration than that for NVs without the ZC configuration, resulting in better anti-tumor effects with minimal toxicities. The vibrating nozzle approach offers significant potential to assemble multi-componential NVs for more efficient anti-tumor treatment and easy user-defined manufacturing of multifunctional nanomedicines.
URI
https://pubs.rsc.org/en/Content/ArticleLanding/2018/NR/C7NR07603G#!divAbstracthttp://repository.hanyang.ac.kr/handle/20.500.11754/105359
ISSN
2040-3364
DOI
10.1039/c7nr07603g
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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