최한곤
2019-05-22T01:19:31Z
2019-05-22T01:19:31Z
2018-02
NANOSCALE, v. 10, No. 4, Page. 1742-1749
2040-3364
https://pubs.rsc.org/en/Content/ArticleLanding/2018/NR/C7NR07603G#!divAbstract
https://repository.hanyang.ac.kr/handle/20.500.11754/105359
A vibrating nozzle approach was used to produce uniform (similar to 2 mu m) hybrid droplets containing gold-graphene oxide (Au-GO), doxorubicin (DOX), and zwitterionic chitosan (ZC) for assembly of Au-GO@ZC-DOX stealth nanovesicles (NVs) via a single-pass diffusion drying process without any hydrothermal reactions, separations, or purifications. NVs were prepared with a lateral dimension of similar to 53.0 nm, a pH-triggered high DOX release profile, and strong photothermal effects. Macrophage opsonization was prevented, resulting in anti-cancer and anti-migration effects, with high intracellular uptake in PANC-1 and MIA PaCa-2 cells. PANC-1 tumor uptake was greater for NVs having the ZC configuration than that for NVs without the ZC configuration, resulting in better anti-tumor effects with minimal toxicities. The vibrating nozzle approach offers significant potential to assemble multi-componential NVs for more efficient anti-tumor treatment and easy user-defined manufacturing of multifunctional nanomedicines.
This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2015R1A2A2A01004118, 2015R1A2A2A04-004806, and 2015R1A2A2A04005809).
en_US
ROYAL SOC CHEMISTRY
LIQUID-CRYSTALLINE NANOPARTICLES
DRUG-DELIVERY-SYSTEMS
IN-VIVO
BREAST-CANCER
CELLULAR UPTAKE
THERAPY
PH
DOXORUBICIN
RELEASE
NANOMEDICINE
Vibrating droplet generation to assemble zwitterion-coated gold-graphene oxide stealth nanovesicles for effective pancreatic cancer chemo-phototherapy
Article
4
10
10.1039/c7nr07603g
1742-1749
NANOSCALE
Thapa, Raj Kumar
Ku, Sae Kwang
Choi, Han-Gon
Yong, Chul Soon
Byeon, Jeong Hoon
Kim, Jong Oh
2018000106
E
COLLEGE OF PHARMACY[E]
DEPARTMENT OF PHARMACY
hangon