Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 조용우 | - |
dc.date.accessioned | 2019-05-02T04:53:36Z | - |
dc.date.available | 2019-05-02T04:53:36Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.citation | ACS APPLIED MATERIALS & INTERFACES, v. 9, No. 10, Page. 8581-8588 | en_US |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://pubs.acs.org/doi/abs/10.1021/acsami.6b16783 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/103142 | - |
dc.description.abstract | Well-designed scaffolds provide appropriate niches that can effectively recruit host cells and induce differentiation of recruited cells into the desired cell types, facilitating in situ tissue regeneration. Here we report a tissue-specific extracellular matrix (ECM) hydrogel composed of adipose-derived soluble ECM (sECM) and methylcellulose (MC) as a cell-free scaffold system for adipose tissue regeneration. The sECM MC hydrogels showed a thermosensitive sol-gel phase transition and rapidly formed a soft hydrogel with a stiffness of 3.8 kPa at body temperature. An in vivo study showed that the sECM MC hydrogel facilitated the infiltration of host cell populations, particularly adipose-derived stem cells (ASCs) and adipose tissue macrophages (ATMs) that directly contribute to the adipose tissue regeneration. Moreover, the hydrogel significantly enhanced host-derived adipogenesis and angiogenesis without exogenous cells or bioactive molecules. Our results indicate that the sECM MC hydrogels provide mechanical and biochemical cues for host-derived adipose regeneration. Overall, the sECM MC hydrogels are a highly promising cell-free therapeutic approach for in situ adipose tissue regeneration. | en_US |
dc.description.sponsorship | This research was supported by the Ministry of Trade, Industry & Energy (MOTIE, Korea) under the Industrial Technology Innovation Program (Grant No. 10062127). This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT & Future Planning (NRF 20100027955 and NRF-2016R1C1B1006882). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | AMER CHEMICAL SOC | en_US |
dc.subject | adipose-derived soluble extracellular matrix | en_US |
dc.subject | cell-free scaffold system | en_US |
dc.subject | host cell recruitment | en_US |
dc.subject | in situ adipose tissue regeneration | en_US |
dc.subject | thermosensitive extracellular matrix hydrogel | en_US |
dc.subject | MESENCHYMAL STEM-CELLS | en_US |
dc.subject | PROGENITOR CELLS | en_US |
dc.subject | GROWTH-FACTOR | en_US |
dc.subject | FAT PAD | en_US |
dc.subject | STIFFNESS | en_US |
dc.subject | ADIPOGENESIS | en_US |
dc.subject | SCAFFOLDS | en_US |
dc.subject | DELIVERY | en_US |
dc.subject | OBESITY | en_US |
dc.subject | REPAIR | en_US |
dc.title | Cell-Free Hydrogel System Based on a Tissue-Specific Extracellular Matrix for In Situ Adipose Tissue Regeneration | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1021/acsami.6b16783 | - |
dc.relation.page | 8581-8588 | - |
dc.relation.journal | ACS APPLIED MATERIALS & INTERFACES | - |
dc.contributor.googleauthor | Kim, Jun Sung | - |
dc.contributor.googleauthor | Choi, Ji Suk | - |
dc.contributor.googleauthor | Cho, Yong Woo | - |
dc.relation.code | 2017001478 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF ENGINEERING SCIENCES[E] | - |
dc.sector.department | DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING | - |
dc.identifier.pid | ywcho7 | - |
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