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Non-alcoholic fatty liver diseases: update on the challenge of diagnosis and treatment

Title
Non-alcoholic fatty liver diseases: update on the challenge of diagnosis and treatment
Author
전대원
Keywords
Non-alcoholic fatty liver; Diagnosis; Treatment
Issue Date
2016-12
Publisher
Korean Association for the Study of the Liver
Citation
Clinical and molecular hepatology, v. 22, Issue 3, Page. 327-335
Abstract
The prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to be 25-30% of the population, and is the most common cause of elevated liver enzymes in Korea. NAFLD is a "hot potato" for pharmaceutical companies. Many clinical trials are underway to develop a first-in-class drug to treat NAFLD. However, there are several challenging issues regarding the diagnosis of NAFLD. Currently, liver biopsy is the gold standard method for the diagnosis of NAFLD and steatohepatitis. Ideally, globally recognized standards for histological diagnosis and methods to optimize observer agreement on biopsy interpretation should be developed. Liver biopsy is the best method rather than a perfect one. Recently, multi-parametric magnetic resonance imagery can estimate the amount of intrahepatic fat successfully and is widely used in clinical trials. But no diagnostic method can discriminate between steatohepatitis and simple steatosis. The other unresolved issue in regard to NAFLD is the absence of satisfactory treatment options. Vitamin E and obeticholic acid have shown protective effects in randomized controlled trials, but this drug has not been approved for use in Korea. This study will provide a description of diagnostic methods and treatments that are currently recommended for NAFLD.
URI
https://www.e-cmh.org/journal/view.php?doi=10.3350/cmh.2016.0049http://repository.hanyang.ac.kr/handle/20.500.11754/102541
ISSN
2287-2728; 2287-285X
DOI
10.3350/cmh.2016.0049
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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