Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bert Binas | - |
dc.date.accessioned | 2019-04-16T05:17:34Z | - |
dc.date.available | 2019-04-16T05:17:34Z | - |
dc.date.issued | 2016-01 | - |
dc.identifier.citation | CLINICAL SCIENCE, v. 130, No. 2, Page. 105-116 | en_US |
dc.identifier.issn | 0143-5221 | - |
dc.identifier.issn | 1470-8736 | - |
dc.identifier.uri | http://www.clinsci.org/content/130/2/105 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/102086 | - |
dc.description.abstract | Although apolipoprotein B100 (ApoB100) plays a key role in peripheral fat deposition, it is not considered a suitable therapeutic target in obesity. In the present study we describe a novel ApoB100 mimotope, peptide pB1, and the use of pB1-based vaccine-like formulations (BVFs) against high-fat diet (HFD)-induced obesity. In HFD-compared with chow-fed adolescent mice, BVFs reduced the 3-month body-weight gains attributable to increased dietary fat by 44-65 %, and prevented mesenteric fat accumulation and liver steatosis. The body-weight reductions paralleled the titres of pB1-reactive immunoglobulin G (IgG) antibodies, and pB1-reactive antibodies specifically recognized native ApoB100 and a synthetic peptide from the C-terminal half of ApoB100. In cultured 3T3L1 adipocytes, anti-pB1 antibodies increased lipolysis and inhibited low-density lipoprotein (LDL) uptake. In cultured RAW 264.7 macrophages, the same antibodies enhanced LDL uptake (without causing foam cell formation). These findings make ApoB100 a promising target for an immunization strategy against HFD-induced obesity. | en_US |
dc.description.sponsorship | This work was supported by the Technology Innovation Program [grant number 10031279, Development of anti-obesity ApoB vaccine] funded by the Ministry of Knowledge Economy of Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PORTLAND PRESS LTD | en_US |
dc.subject | ApoB100 | en_US |
dc.subject | high-fat-diet-induced obesity | en_US |
dc.subject | humoral immunity | en_US |
dc.subject | mimotope | en_US |
dc.title | An apolipoprotein B100 mimotope prevents obesity in mice | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 130 | - |
dc.identifier.doi | 10.1042/CS20150423 | - |
dc.relation.page | 105-116 | - |
dc.relation.journal | CLINICAL SCIENCE | - |
dc.contributor.googleauthor | Kim, Hyo Joon | - |
dc.contributor.googleauthor | Lee, Hee Jong | - |
dc.contributor.googleauthor | Choi, Jung Soon | - |
dc.contributor.googleauthor | Han, Jemin | - |
dc.contributor.googleauthor | Kim, Ji Young | - |
dc.contributor.googleauthor | Na, Hyun Kyun | - |
dc.contributor.googleauthor | Joung, Hae-Jung | - |
dc.contributor.googleauthor | Kim, Young Sik | - |
dc.contributor.googleauthor | Binas, Bert | - |
dc.relation.code | 2016002349 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF MOLECULAR AND LIFE SCIENCE | - |
dc.identifier.pid | bbinas | - |
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