주사 치료 방법에 따른 임상적 효과에 대한 고찰

Abstract

Background: Recently, a combination of therapeutic modalities has been used to treat rosacea. Oral therapy with minocycline or isotretinoin is effective in the initial control of rosacea, and intense pulsed light (IPL) is a useful alternative laser therapy for rosacea. However, no comparative studies have investigated minocycline monotherapy or the combination of isotretinoin either with or without IPL Objective: We aimed to investigate the clinical efficacies of minocycline alone compared to the consecutive therapy of isotretinoin with or without IPL for the treatment of rosacea. Methods: Sixty-six patients were included in this study. Every patient applied topical 0.75% metronidazole twice a day. The patients were classified into the following three groups: minocycline alone for 6 months (Group 1, n=23), the consecutive isotretinoin of 3 months after minocycline alone for the first 3 months (Group 2, n=21), and 3 months of minocycline and consecutive 3 months of isotretinoin with adjuvant IPL (Group 3, n=22). In Group 3, total 4 sessions of IPL treatments were administered to the face every three weeks for 3 months during taking isotretinoin. Two independent physicians determined the clinical efficacy using a scale from 0–3 to evaluate the severity of erythema and telangiectasia; they also counted the number of inflammatory lesions (papules and pustules) at every visit until the completion of six months of treatment. Results: An improvement in the inflammatory lesions was evident in every group. In the Group 3 showed greater improvement in their inflammatory lesion count and erythema than Group 1 and Group 2 (p<0.001 and p=0.012, respectively). Conclusions: Oral therapy and IPL were both effective for the treatment of rosacea. The combination of oral minocycline and isotretinoin markedly decreased the inflammation of lesions, although IPL was more effective in improving the erythema and inflammatory lesions.