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Clinical manifestation of Tenosynovitis Pattern on Two-phase Bone Scintigraphy in Suspected Rheumatoid Arthritis

Title
Clinical manifestation of Tenosynovitis Pattern on Two-phase Bone Scintigraphy in Suspected Rheumatoid Arthritis
Other Titles
류마티스 관절염 의증 환자에서 이상 골스캔(Two-Phase Bone Scan)에서의 힘줄막염(Tenosynovitis)의 유형과 임상양상 분석
Author
최형진
Alternative Author(s)
CHOI, Hyung Jin
Advisor(s)
최윤영
Issue Date
2019-02
Publisher
한양대학교
Degree
Master
Abstract
Purpose: To investigate the correlation between tenosynovitis pattern on two-phase bone scintigraphy (2P-BS) and clinical manifestation in patients with suspected rheumatoid arthritis (RA). Materials and Method: 2P-BS including technetium 99m-methyl diphosphonate (99mTc-MDP) blood pool and bone phase imaging in 402 consecutive patients (19-81 years old
mean 48.3 years old) with clinically suspected RA were retrospectively reviewed. According to 2010 RA Classification Criteria, patients were grouped as RA and non-RA. Visual assessment of all fingers, toes, wrists, and ankles on 2P-BS was performed: linear increased activity on the blood pool image with/without focal bone uptake was interpreted as tenosynovitis. Clinical suspected tenosynovitis was evaluated on physical examination. Laboratory data including rheumatoid factor (RF), anti-cyclic citrullinated protein antibody (ACPA), C-reactive protein (CRP), and estimated sedimentation rate (ESR) were obtained. Radiographic findings were also used to define early and established arthritis. Results: Tenosynovitis pattern was detected in 51 on 2P-BS of 402 patients (12.7%). Of the 51 patients, 48 patients (94.1%) were diagnosed as RA vs. 3 patients (5.9%) as non-RA. Of the 48 RA patients with positive 2P-BS finding, 41 patients (85.4%) had early arthritis and 7 patients (14.6%) had established arthritis. On physical examination, tenosynovitis was suspected in 88 of 402 patients (21.9%). 56.8% belonged to RA group (50/88) and 43.2% to non-RA group (38/88). The tenosynovitis pattern of 2P-BS and physical examination for 402 patients showed statistical difference and moderate agreement. The positive tenosynovitis pattern on 2P-BS represented up to 26.408 of Odds ratio that was highest among those of the RA-associated factors. Conclusion: Tenosynovitis pattern either on 2P-BS or physical examination was more commonly detected in RA group, compared to non-RA group. Tenosynovitis pattern was more frequently associated with RA especially early arthritis pattern than established arthritis. 2P-BS could give additional information for the prediction of the disease progression in the preclinical or early stage of RA.
URI
https://repository.hanyang.ac.kr/handle/20.500.11754/99569http://hanyang.dcollection.net/common/orgView/200000434402
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > MEDICINE(의학과) > Theses (Master)
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