Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김도균 | - |
dc.date.accessioned | 2019-02-27T02:15:01Z | - |
dc.date.available | 2019-02-27T02:15:01Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v. 8, Article no. 15807 | en_US |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://www.nature.com/articles/ncomms15807 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/99260 | - |
dc.description.abstract | Tissue adhesives have emerged as an alternative to sutures and staples for wound closure and reconnection of injured tissues after surgery or trauma. Owing to their convenience and effectiveness, these adhesives have received growing attention particularly in minimally invasive procedures. For safe and accurate applications, tissue adhesives should be detectable via clinical imaging modalities and be highly biocompatible for intracorporeal procedures. However, few adhesives meet all these requirements. Herein, we show that biocompatible tantalum oxide/silica core/shell nanoparticles (TSNs) exhibit not only high contrast effects for real-time imaging but also strong adhesive properties. Furthermore, the biocompatible TSNs cause much less cellular toxicity and less inflammation than a clinically used, imageable tissue adhesive (that is, a mixture of cyanoacrylate and Lipiodol). Because of their multifunctional imaging and adhesive property, the TSNs are successfully applied as a hemostatic adhesive for minimally invasive procedures and as an immobilized marker for image-guided procedures. | en_US |
dc.description.sponsorship | T.H. acknowledges financial support by the Research Center Program of Institute for Basic Science (IBS) in Korea (IBS-R006-D1). H.-C.K. acknowledges a grant from the Seoul National University Hospital (SNUH) Research Fund (04-2013-0790). N.L. acknowledges financial support by the Marine Biotechnology Program (20150220) funded by the Ministry of Oceans and Fisheries, Basic Science Research Program (2015R1C1A1A01053463), and Foreign Research Institute Recruitment Program (2013K1A4A3055679) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | RAY-COMPUTED-TOMOGRAPHY | en_US |
dc.subject | TANTALUM OXIDE NANOPARTICLES | en_US |
dc.subject | UP-CONVERSION NANOPARTICLES | en_US |
dc.subject | CONTRAST AGENTS | en_US |
dc.subject | THERANOSTIC NANOPARTICLES | en_US |
dc.subject | BIOLOGICAL PERFORMANCE | en_US |
dc.subject | MESOPOROUS SILICA | en_US |
dc.subject | SURGERY | en_US |
dc.subject | CANCER | en_US |
dc.subject | FLUORESCENCE | en_US |
dc.title | Multifunctional nanoparticles as a tissue adhesive and an injectable marker for image-guided procedures | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/ncomms15807 | - |
dc.relation.journal | NATURE COMMUNICATIONS | - |
dc.contributor.googleauthor | Shin, Kwangsoo | - |
dc.contributor.googleauthor | Choi, Jin Woo | - |
dc.contributor.googleauthor | Ko, Giho | - |
dc.contributor.googleauthor | Baik, Seungmin | - |
dc.contributor.googleauthor | Kim, Dokyoon | - |
dc.contributor.googleauthor | Park, Ok Kyu | - |
dc.contributor.googleauthor | Lee, Kyoungbun | - |
dc.contributor.googleauthor | Cho, Hye Rim | - |
dc.contributor.googleauthor | Han, Sang Ihn | - |
dc.contributor.googleauthor | Lee, Soo Hong | - |
dc.contributor.googleauthor | Lee, Dong Jun | - |
dc.contributor.googleauthor | Lee, Nohyun | - |
dc.contributor.googleauthor | Kim, Hyo-Cheol | - |
dc.contributor.googleauthor | Hyeon, Taeghwan | - |
dc.relation.code | 2017003407 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF ENGINEERING SCIENCES[E] | - |
dc.sector.department | DEPARTMENT OF BIONANO ENGINEERING | - |
dc.identifier.pid | kimdk | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.