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Characterization of Polycaprolactone and Rice Husk Silica Composite (PCL-SiO2) by E-Spinning to Apply Supporter for Drug Release

Title
Characterization of Polycaprolactone and Rice Husk Silica Composite (PCL-SiO2) by E-Spinning to Apply Supporter for Drug Release
Author
김희택
Issue Date
2018-04
Publisher
Institute of Physics
Citation
Journal of Physics: Conference Series, v. 987, No. 1, Article no. 012013
Abstract
Polycaprolactone (PCL) is an interesting material to apply biomedical field owing to its biodegradability and biocompatibility which is suitable for a specific site with longer healing times. Blending the polymer with other materials has degradation property improved with the effective and economic method. This study was conducted to fabricate supporter based on Polycaprolactone and Rice husk silica (PCL-SiO2) by using electrospinning. Nano-porous silica in the composite was synthesized from rice husk having properties of economic, eco-friendly and high surface area. It drew to enhance the amount of drug loading in the carrier. Electrospinning technique is used to fabricate fibrous component by optimization condition obtained from previous mechanical properties experiments. Release experiment was carried out by the degree of dye absorbance at 544nm by ultraviolet-visible spectroscopy, the RhB in SiO2 alternative drug for modelling of drug release was released for 1 ∼ 20 days at 37°C in phosphate buffer. Furthermore, the Mechanical property was confirmed by DSC, TGA. Morphology and degree of biodegradation were shown as SEM images and EDS. © Published under licence by IOP Publishing Ltd.
URI
https://iopscience.iop.org/article/10.1088/1742-6596/987/1/012013/metahttps://repository.hanyang.ac.kr/handle/20.500.11754/99107
ISSN
1742-6588
DOI
10.1088/1742-6596/987/1/012013
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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