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Tissue distribution of gold and silver after subacute intravenous injection of co-administered gold and silver nanoparticles of similar sizes

Title
Tissue distribution of gold and silver after subacute intravenous injection of co-administered gold and silver nanoparticles of similar sizes
Author
안강호
Keywords
Silver nanoparticles; Gold nanoparticles; Subacute intraveneous injection; Co-administration; Tissue distribution; Toxicokinetics
Issue Date
2018-04
Publisher
SPRINGER HEIDELBERG
Citation
ARCHIVES OF TOXICOLOGY, v. 92, No. 4, Page. 1393-1405
Abstract
Gold (AuNPs, 12.8 nm) and silver nanoparticles (AgNPs, 10 nm), mixed or separate, were injected into the caudal vein of male Sprague-Dawley rats for 4 weeks. The rats were allowed to recover for further 4 weeks to examine the differences in AuNP/AgNP tissue distribution and clearance. The size distribution of injected AuNPs and AgNPs were not statistically different. The dose groups (five males per group for the administration and three males for the recovery) consisted of seven divisions, i.e., control, AgNPs (with a low dose of 10 mu g/kg/day, and, a high dose of 100 mu g/kg/day), AuNPs (with a low dose of 10 mu g/kg/day, and, a high dose of 100 mu g/kg/day), as well as mixed AgNPs/AuNPs (with a low dose of 10/10 mu g/kg/day, and a high dose of 100/100 mu g/kg/day). The AgNPs accumulated in a dose-dependent manner in the liver, spleen, kidneys, lung, brain, testis or blood. Au concentration increased also in a dose-dependent manner in the liver, kidneys, spleen and lungs, but not in the brain, testis and blood. Ag concentration in the tissues increased dose-dependently after 4 weeks of AgNP/AuNP mixed administration, but to a much lower extent than those observed when they were administered separately. Ag concentration in the tissues after 4 weeks of AgNP/AuNP mixed administration cleared dose-dependently after 4 weeks of recovery. Au concentration in the tissues increased dose-dependently after 4 weeks of AgNp/AuNP mixed administration, while Au concentration in the tissues did not clear as seen in Ag after 4 weeks recovery. Au concentration showed biopersistency or accumulation in the liver, kidneys, spleen and brain of the 4 weeks of recovery. In conclusion, AgNPs and AuNPs showed different toxicokinetic properties and the mixed administration of AgNPs with AuNPs resulted in mutual reduction of their tissue distribution which appeared to be due to competitive inhibition. Furthermore, this subacute intravenous injection study has suggested that these nanoparticles were distributed to the organs in particulate instead of ionic forms.
URI
https://link.springer.com/article/10.1007/s00204-018-2173-4https://repository.hanyang.ac.kr/handle/20.500.11754/99099
ISSN
0340-5761; 1432-0738
DOI
10.1007/s00204-018-2173-4
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MECHANICAL ENGINEERING(기계공학과) > Articles
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