Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장기석 | - |
dc.date.accessioned | 2019-02-13T06:01:24Z | - |
dc.date.available | 2019-02-13T06:01:24Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v. 239, Page. 231-241 | en_US |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.issn | 1873-4995 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0168365916305351?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/98950 | - |
dc.description.abstract | Elevated level of tumor necrosis factor-alpha (TNF-alpha), one of the inflammatory cytokines, is considered to be a potential target for the inflammatory bowel disease (IBD) therapy. Recently, TNF-alpha converting enzyme (TACE), a sheddase playing an important role in cleaving and releasing bioactive soluble TNF-alpha, has been challenged with inhibitors to treat inflammatory diseases. Here, we report a novel anti-TNF-alpha strategy using a short hairpin RNA silencing TACE (shTACE) to prevent and treat colitis. The shTACE formed stable complexes with nona-arginine-based bio-cleavable disulfide bond-linked poly (arginine) (PAs-s) for enhanced gene delivery. Systemically administered shTACE/PAs-s peptoplexes efficiently decreased TNF-alpha levels, increased survival and alleviated pathophysiological parameters representing colitis severity. Our results demonstrate effectiveness and safety of shTACE/PAs-s peptoplexes with the capacity of overcoming acute and chronic ulcerative colitis through modulation of excessive inflammatory responses in the colon, providing a strong potential as a therapeutic agent for a broad variety of inflammatory diseases. (C) 2016 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This work was partially supported by grants from the National Research Foundation of Korea (2014R1A2A1A11049587, 2015R1A2A1A09003019), the Brain Korea 21 plus program (22A20130011095), the Korean Health Technology R&D project through the Ministry of Health & Welfare (HI13C-1938-010015) and Basic Science Research Program through the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2014R1A1A1006117). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | RNA interference | en_US |
dc.subject | Tumor necrosis factor-alpha | en_US |
dc.subject | TNF-alpha converting enzyme | en_US |
dc.subject | Inflammatory bowel disease | en_US |
dc.title | RNAi-mediated silencing of TNF-alpha converting enzyme to down-regulate soluble TNF-alpha production for treatment of acute and chronic colitis | en_US |
dc.type | Article | en_US |
dc.relation.volume | 239 | - |
dc.identifier.doi | 10.1016/j.jconrel.2016.08.017 | - |
dc.relation.page | 231-241 | - |
dc.relation.journal | JOURNAL OF CONTROLLED RELEASE | - |
dc.contributor.googleauthor | Song, Yoonsung | - |
dc.contributor.googleauthor | Kim, Ye-Ram | - |
dc.contributor.googleauthor | Kim, So Mi | - |
dc.contributor.googleauthor | Ain, Qurrat Ul | - |
dc.contributor.googleauthor | Jang, Kiseok | - |
dc.contributor.googleauthor | Yang, Chul-Su | - |
dc.contributor.googleauthor | Kim, Yong-Hee | - |
dc.relation.code | 2016002955 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | medartisan | - |
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