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Facile fabrication of highly photothermal-effective albumin-assisted gold nanoclusters for treating breast cancer

Title
Facile fabrication of highly photothermal-effective albumin-assisted gold nanoclusters for treating breast cancer
Author
최한곤
Keywords
Gold nanoclusters; Albumin; Hyperthermia; Top-down process; Antitumor efficacy; Breast cancer
Issue Date
2018-11
Publisher
ELSEVIER SCIENCE BV
Citation
INTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 553, No. 1-2, Page. 363-374
Abstract
Gold nanoclusters (AuNCs) have been considered to be a promising candidate for hyperthermia-based anticancer therapy. Herein, we introduce albumin-assisted AuNCs composed of small gold nanoparticles (AuNPs, < 6 nm) assembled with strands of polyallylamine (PAH), which exhibited strong surface plasmon resonance upon nearinfrared (NIR, similar to 808 nm) laser irradiation and good in vivo stability. Our albumin-assisted PAH-AuNCs (BSA/PAH-AuNCs) were facilely fabricated as a top-down process by a simple ultrasonication after the preparation of large nano-aggregates of PAH-AuNPs. Albumin played a critical role as a stabilizer and surfactant in making loosely associated large aggregates and thereby producing small gold nanoclusters (similar to 60 nm) of slightly negative charge upon ultrasonication. The prepared BSA/PAH-AuNCs displayed excellent hyperthermal effects (similar to 60 degrees C) in response to similar to 808-nm NIR laser irradiation in a 4T1 cell system in vitro and in 4T1 cell tumor xenograft mice in vivo, indicating their remarkable potential to suppress breast cancer growth, without almost no significant toxicity in histology. Consequently, our gold nanoclusters should be considered as a promising photothermal agent that are easy to manufacture and exhibit marked anticancer effects in terms of tumor ablation.
URI
https://www.sciencedirect.com/science/article/pii/S0378517318308068https://repository.hanyang.ac.kr/handle/20.500.11754/98768
ISSN
0378-5173; 1873-3476
DOI
10.1016/j.ijpharm.2018.10.063
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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