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Folate receptor-mediated celastrol and irinotecan combination delivery using liposomes for effective chemotherapy

Title
Folate receptor-mediated celastrol and irinotecan combination delivery using liposomes for effective chemotherapy
Author
최한곤
Keywords
Breast cancer; Celastrol; Folic acid; Irinotecan; Liposomes
Issue Date
2018-07
Publisher
ELSEVIER SCIENCE BV
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, v. 170, Page. 718-728
Abstract
Drug targeting using functionalized nanoparticles provides a new standard in anticancer therapy. Liposomes, safe and effective drug delivery carriers, can incorporate both hydrophilic and hydrophobic drugs for combination chemotherapy treatment of cancers. The objectives of the current study were to synthesize and test the effectiveness of a nanotechnology-based strategy utilizing folic acid (FA)-conjugated liposomes that incorporate both celastrol (Cs) and irinotecan (Ir) for targeted breast cancer therapy. Our results revealed the successful preparation of Cs and Ir-loaded folate-targeted liposomes (Lipo/Cs/Ir-FA) with a small particle size (similar to 190 nm) and polydispersity index (similar to 0.10). The formulation exhibited higher drug release profiles for both Ir and Cs at pH 5.0 compared to those at physiological pH, favoring cancer cell-targeted release. Furthermore, in vitro cell studies showed high uptake and enhanced apoptosis in folate receptor-positive breast cancer cells (MCF-7 and MDA-MB231), but not in folate receptor-negative lung cancer cells (A549). Moreover, an in vivo study in a mouse tumor model using MDA-MB-231 xenografts supported effective drug delivery behavior of the folate-conjugated liposomes by selective targeting of tumor tissue and minimizing systemic adverse effects. Therefore, our formulation could provide an effective therapy for targeted cancer treatment.
URI
https://www.sciencedirect.com/science/article/pii/S0927776518304600https://repository.hanyang.ac.kr/handle/20.500.11754/81227
ISSN
0927-7765
DOI
10.1016/j.colsurfb.2018.07.013
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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