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dc.contributor.author최한곤-
dc.date.accessioned2019-01-09T04:57:54Z-
dc.date.available2019-01-09T04:57:54Z-
dc.date.issued2018-06-
dc.identifier.citationCOLLOIDS AND SURFACES B-BIOINTERFACES, v. 169, Page. 429-437en_US
dc.identifier.issn0927-7765-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0927776518303357-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/81165-
dc.description.abstractIntratumoral injection of nanoparticles is a viable alternative for treating solid tumors. In this study, we used intratumorally-injected palladium nanoparticle (Pd NP)-decorated graphene oxide (GO) (GO-Pd NPs) for the treatment of solid prostate tumors. GO was synthesized using the modified Hummer's method and GO-Pd NPs were prepared using the one pot synthesis method. Studies on physicochemical characterization and in vitro/in vivo anticancer properties were performed using GO-Pd NPs. Successful preparation of GO-Pd NPs was confirmed by transmission electron microscopy, Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Compared to GO or Pd NPs alone, GO-Pd NPs showed higher cytotoxic effects in prostate cancer 3 (PC3) cells. Irradiation of treated cells with near infrared (NIR) laser considerably enhanced apoptosis induced by synergistic photothermal effect and reactive oxygen species (ROS) generation. Intratumorally-injected GO-Pd NPs showed promising in vivo localized distribution, photothermal ablation, and anti-tumor effects in the PC3 xenograft mouse model. Furthermore, the minimal organ toxicity of GO-Pd NPs was an added advantage. Hence, GO-Pd NPs could be a potential formulation for localized treatment of prostate solid tumors.en_US
dc.description.sponsorshipThis research was supported by the Medical Research Center Program (2015R1A5A2009124) through the National Research Foundation of Korea (NRF) grant, and Kyungpook National University Research Fund, 2015.en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectGraphene oxideen_US
dc.subjectPalladium nanoparticlesen_US
dc.subjectPhotothermal therapyen_US
dc.subjectProstate canceren_US
dc.subjectReactive oxygen speciesen_US
dc.titlePalladium nanoparticle-decorated 2-D graphene oxide for effective photodynamic and photothermal therapy of prostate solid tumorsen_US
dc.typeArticleen_US
dc.relation.volume169-
dc.identifier.doi10.1016/j.colsurfb.2018.05.051-
dc.relation.page429-437-
dc.relation.journalCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.contributor.googleauthorThapa, Raj Kumar-
dc.contributor.googleauthorSoe, Zar Chi-
dc.contributor.googleauthorOu, Wenquan-
dc.contributor.googleauthorPoudel, Kishwor-
dc.contributor.googleauthorJeong, Jee-Heon-
dc.contributor.googleauthorJin, Sung Giu-
dc.contributor.googleauthorKu, Sae Kwang-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorLee, You Mie-
dc.contributor.googleauthorYong, Chul Soon-
dc.contributor.googleauthorKim, Jong Oh-
dc.relation.code2018001466-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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