Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-01-09T04:57:54Z | - |
dc.date.available | 2019-01-09T04:57:54Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | COLLOIDS AND SURFACES B-BIOINTERFACES, v. 169, Page. 429-437 | en_US |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0927776518303357 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/81165 | - |
dc.description.abstract | Intratumoral injection of nanoparticles is a viable alternative for treating solid tumors. In this study, we used intratumorally-injected palladium nanoparticle (Pd NP)-decorated graphene oxide (GO) (GO-Pd NPs) for the treatment of solid prostate tumors. GO was synthesized using the modified Hummer's method and GO-Pd NPs were prepared using the one pot synthesis method. Studies on physicochemical characterization and in vitro/in vivo anticancer properties were performed using GO-Pd NPs. Successful preparation of GO-Pd NPs was confirmed by transmission electron microscopy, Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Compared to GO or Pd NPs alone, GO-Pd NPs showed higher cytotoxic effects in prostate cancer 3 (PC3) cells. Irradiation of treated cells with near infrared (NIR) laser considerably enhanced apoptosis induced by synergistic photothermal effect and reactive oxygen species (ROS) generation. Intratumorally-injected GO-Pd NPs showed promising in vivo localized distribution, photothermal ablation, and anti-tumor effects in the PC3 xenograft mouse model. Furthermore, the minimal organ toxicity of GO-Pd NPs was an added advantage. Hence, GO-Pd NPs could be a potential formulation for localized treatment of prostate solid tumors. | en_US |
dc.description.sponsorship | This research was supported by the Medical Research Center Program (2015R1A5A2009124) through the National Research Foundation of Korea (NRF) grant, and Kyungpook National University Research Fund, 2015. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Graphene oxide | en_US |
dc.subject | Palladium nanoparticles | en_US |
dc.subject | Photothermal therapy | en_US |
dc.subject | Prostate cancer | en_US |
dc.subject | Reactive oxygen species | en_US |
dc.title | Palladium nanoparticle-decorated 2-D graphene oxide for effective photodynamic and photothermal therapy of prostate solid tumors | en_US |
dc.type | Article | en_US |
dc.relation.volume | 169 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2018.05.051 | - |
dc.relation.page | 429-437 | - |
dc.relation.journal | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.contributor.googleauthor | Thapa, Raj Kumar | - |
dc.contributor.googleauthor | Soe, Zar Chi | - |
dc.contributor.googleauthor | Ou, Wenquan | - |
dc.contributor.googleauthor | Poudel, Kishwor | - |
dc.contributor.googleauthor | Jeong, Jee-Heon | - |
dc.contributor.googleauthor | Jin, Sung Giu | - |
dc.contributor.googleauthor | Ku, Sae Kwang | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.contributor.googleauthor | Lee, You Mie | - |
dc.contributor.googleauthor | Yong, Chul Soon | - |
dc.contributor.googleauthor | Kim, Jong Oh | - |
dc.relation.code | 2018001466 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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