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dc.contributor.author김동욱-
dc.date.accessioned2018-12-20T06:20:05Z-
dc.date.available2018-12-20T06:20:05Z-
dc.date.issued2018-03-
dc.identifier.citationFRONTIERS IN PEDIATRICS, v. 6, Article no. 57en_US
dc.identifier.issn2296-2360-
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fped.2018.00057/full-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/80971-
dc.description.abstractThe rapid, accurate, and efficient identification of an infectious disease is critical to ensure timely clinical treatment and prevention in public health settings. In 2015, meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis was responsible for 379,200 (range: 322,700-444,700) deaths. Clinical features alone cannot determine whether bacterial meningitis is present; an analysis of cerebrospinal fluid (CSF) is essential. Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification method offering an alternative to polymerase chain reaction (PCR). LAMP-based assays for detection of three leading bacteria in CSF for diagnosis of meningitis have been established. The typing assays using LAMP for detection of meningococcal serogroups A, B, C, W, X, and Y as well as H. influenzae serotypes a, b, c, d, e, and f were launched. In comparative analysis of the meningitis pathogen assays, LAMP assays did not yield false negative results, and the detection rate of LAMP assays was superior compared with PCR or conventional culture methods. LAMP assays provide accurate and rapid test results to detect major bacterial meningitis pathogens. Accumulating evidence suggests that LAMP assays have the potential to provide urgently needed diagnostics for bacterial meningitis in resource-limited settings of both developed and developing countries.en_US
dc.description.sponsorshipThis project was supported by JSPS Bilateral Open Partnership Joint Research Projects (MS). DK was supported by the grant NRF-2015R1A2A2A01007297 and NRF-2015M3C9A2054024 from National Research Foundation (NRF) of Korea.en_US
dc.language.isoen_USen_US
dc.publisherFRONTIERS MEDIA SAen_US
dc.subjectloop-mediated isothermal amplificationen_US
dc.subjectmeningitisen_US
dc.subjectcerebrospinal fluiden_US
dc.subjectNeisseria meningitidisen_US
dc.subjectHaemophilus influenzaeen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.subjectserotype identificationen_US
dc.titleLoop-Mediated isothermal Amplification Methods for Diagnosis of Bacterial Meningitisen_US
dc.typeArticleen_US
dc.relation.volume6-
dc.identifier.doi10.3389/fped.2018.00057-
dc.relation.page57-57-
dc.relation.journalFRONTIERS IN PEDIATRICS-
dc.contributor.googleauthorSeki, Mitsuko-
dc.contributor.googleauthorKilgore, Paul E.-
dc.contributor.googleauthorKim, Eun Jin-
dc.contributor.googleauthorOhnishi, Makoto-
dc.contributor.googleauthorHayakawa, Satoshi-
dc.contributor.googleauthorKim, Dong Wook-
dc.relation.code2018007534-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.piddongwook-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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