60 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author정지은-
dc.date.accessioned2018-12-17T01:34:05Z-
dc.date.available2018-12-17T01:34:05Z-
dc.date.issued2018-01-
dc.identifier.citationGENE, v. 641, Page. 68-73en_US
dc.identifier.issn0378-1119-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378111917308958-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/80892-
dc.description.abstractThe aim of this study was to investigate the possible effects of EPHX1 and VKORC1L1 polymorphisms on variability of responses to warfarin. Sixteen single nucleotide polymorphisms (SNPs) in 201 patients with stable warfarin doses were analyzed including genes of VKORC1, CYP2C9, CYP4F2, GGCX, EPHX1 and VKORC1L1. Univariate analysis was conducted for the association of genotypes with stable warfarin doses. Multiple linear regression analysis was used to investigate factors that independently affected the inter-individual variability of warfarin dose requirements. The rs4072879 of VKORC1L1 (A > G) was significantly associated with stable warfarin doses; wild homozygote carriers (AA) required significantly lower stable warfarin doses than those with the variant G allele (5.02 +/- 1.56 vs. 5.96 +/- 2.01 mg; p = 0.001). Multivariate analysis showed that EPHX1 rs1877724 and VKORC1L1 rs4072879 accounted for 1.5% and 1.3% of the warfarin dose variability. Adding EPHX1 and VKORC1L1 SNPs to the base model including non-genetic variables (operation age, body weight and the therapy of ACEI or ARB) and genetic variables (VKORC1 rs9934438, CYP2C9 rs1057910, and CYP4F2 rs2108622) gave a number needed to genotype of 34. This study showed that polymorphisms of EPHX1 and VKORC1L1 could be determinants of stable warfarin doses.en_US
dc.description.sponsorshipThis research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2017R1D1A1B03034033).en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectEpoxide hydrolase 1en_US
dc.subjectVKORC1L1en_US
dc.subjectVitamin K cycleen_US
dc.subjectGenetic polymorphismen_US
dc.subjectStable warfarin dosesen_US
dc.subjectNumber needed to genotypeen_US
dc.titlePolymorphisms of vitamin K-related genes (EPHX1 and VKORC1L1) and stable warfarin dosesen_US
dc.typeArticleen_US
dc.relation.volume641-
dc.identifier.doi10.1016/j.gene.2017.10.049-
dc.relation.page68-73-
dc.relation.journalGENE-
dc.contributor.googleauthorChung, Jee-Eun-
dc.contributor.googleauthorLee, Kyung Eun-
dc.contributor.googleauthorChang, Byung Chul-
dc.contributor.googleauthorGwak, Hye Sun-
dc.relation.code2018006221-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidjechung-
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE