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Grifola frondosa (Maitake Mushroom) Water Extract Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis Through Inhibition of Reactive Oxygen Species and Extracellular Signal-Regulated Kinase Phosphorylation

Title
Grifola frondosa (Maitake Mushroom) Water Extract Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis Through Inhibition of Reactive Oxygen Species and Extracellular Signal-Regulated Kinase Phosphorylation
Author
최한곤
Keywords
angiogenesis; extracellular signal-regulated kinase; Grifola frondosa fruiting body; reactive oxygen species; vascular endothelial growth factor
Issue Date
2008-12
Publisher
MARY ANN LIEBERT, INC
Citation
Journal of Medicinal Food, v. 11, No. 4, Page. 643-651
Abstract
Grifola frondosa, a large edible mushroom also known as maitake, has been used as a health food for centuries in China and Japan. In the present study, we examined anti-angiogenic activity of a water extract of the fruiting body of G. frondosa (GFW). An in vivo angiogenesis assay using chick chorioallantoic membrane revealed that GFW (1-100 mu g/mL) dose-dependently inhibited vascular endothelial growth factor (VEGF)-induced angiogenesis. In addition, GFW inhibited VEGF-induced proliferation, chemotactic migration, and capillary-like tube formation of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. Upon stimulation by VEGF, HUVECs rapidly increased reactive oxygen species production, which was significantly blocked by the treatment with GFW. Moreover, phosphorylation of extracellular signal-regulated kinase 1/2, a downstream signaling molecule following VEGF receptor activation, was also inhibited by GFW. The results indicate that GFW effectively inhibit angiogenesis by blocking VEGF signaling and suggest that G. frondosa fruiting body may be a valuable medicinal food for treatment of angiogenesis-associated human diseases.
URI
https://www.liebertpub.com/doi/abs/10.1089/jmf.2007.0629https://repository.hanyang.ac.kr/handle/20.500.11754/80857
ISSN
1096-620X
DOI
10.1089/jmf.2007.0629
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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