Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고현철 | - |
dc.date.accessioned | 2018-11-14T02:10:16Z | - |
dc.date.available | 2018-11-14T02:10:16Z | - |
dc.date.issued | 2016-09 | - |
dc.identifier.citation | TOXICOLOGY LETTERS, v. 258, Page. 36-45 | en_US |
dc.identifier.issn | 0378-4274 | - |
dc.identifier.issn | 1879-3169 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0378427416301515?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/80393 | - |
dc.description.abstract | Inflammatory responses are involved in mechanisms of neuronal cell damage in the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD). We investigated the mechanisms whereby inflammatory responses contribute to loss of dopaminergic neurons in fipronil (FPN)-treated rats. After stereotaxic injection of FPN in the substantia nigra (SN), the number of tyrosine hydroxylase (TH)-positive neurons and the levels of TH expression in the SN decreased at 7 days, and a significant decrease was observed at 14 days with a subsequent reduction in striatal TH expression. Decreases in dopamine (DA) levels, however, began at 3 days post-injection, preceding the changes in TH expression. In contrast, glial fibrillary acidic protein (GFAP) expression was significantly increased at 3 days and persisted for up to 14 days post-lesion; these changes in GFAP expression appeared to be inversely correlated with TH expression. Furthermore, we found that FPN administration induced an inflammatory response characterized by increased levels of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha), which was mediated by activated microglia following infusion of FPN unilaterally into the SN. Intranigral injection of FPN underwent an inflammatory response with a resultant ongoing loss of dopaminergic neurons, indicating that pesticides may have important implication for the study of PD. Crown Copyright (C) 2016 Published by Elsevier Ireland Ltd. All | en_US |
dc.description.sponsorship | This work was supported by the Korea Science and Engineering Foundation (NRF-2008-0062287) through the Medical Research Center at Hanyang University College of Medicine, Republic of Korea, and by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2015R1D1A1A01059531). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER IRELAND LTD | en_US |
dc.subject | Fipronil | en_US |
dc.subject | Dopaminergic neuron | en_US |
dc.subject | Cyclooxygenase-2 | en_US |
dc.subject | Inducible NO synthase | en_US |
dc.subject | Inflammation | en_US |
dc.title | Progressive loss of nigrostriatal dopaminergic neurons induced by inflammatory responses to fipronil | en_US |
dc.type | Article | en_US |
dc.relation.volume | 258 | - |
dc.identifier.doi | 10.1016/j.toxlet.2016.06.011 | - |
dc.relation.page | 36-45 | - |
dc.relation.journal | TOXICOLOGY LETTERS | - |
dc.contributor.googleauthor | Park, Jae Hyeon | - |
dc.contributor.googleauthor | Park, Youn Sun | - |
dc.contributor.googleauthor | Koh, Hyun Chul | - |
dc.relation.code | 2016001367 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hckoh | - |
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