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dc.contributor.author김담-
dc.date.accessioned2018-11-12T07:52:11Z-
dc.date.available2018-11-12T07:52:11Z-
dc.date.issued2016-09-
dc.identifier.citationKOREAN JOURNAL OF INTERNAL MEDICINE, v. 32, no. 4, Page. 738-746en_US
dc.identifier.issn1226-3303-
dc.identifier.issn2005-6648-
dc.identifier.urihttp://kjim.org/journal/view.php?doi=10.3904/kjim.2015.364-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/80337-
dc.description.abstractBackground/Aims: To determine whether early diagnosis is beneficial for functional status of various disease durations in rheumatoid arthritis (RA) patients. Methods: A total of 4,540 RA patients were enrolled as part of the Korean Observational Study Network for Arthritis (KORONA). We defined early diagnosis as a lag time between symptom onset and RA diagnosis of <= 12 months, whereas patients with a longer lag time comprised the delayed diagnosis group. Demographic characteristics and outcomes were compared between early and delayed diagnosis groups. Logistic regression analyses were performed to identify the impact of early diagnosis on the development of functional disability in RA patients. Results: A total of 2,597 patients (57.2%) were included in the early diagnosis group. The average Health Assessment Questionnaire-Disability Index (HAQ-DI) score was higher in the delayed diagnosis group (0.64 +/- 0.63 vs. 0.70 +/- 0.66, p < 0.01), and the proportion of patients with no functional disability (HAQ = 0) was higher in the early diagnosis group (22.9% vs. 20.0%, p = 0.02). In multivariable analyses, early diagnosis was independently associated with no functional disability (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.01 to 1.40). In a subgroup analysis according to disease duration, early diagnosis was associated with no functional disability in patients with disease duration < 5 years (OR, 1.37; 95% CI, 1.09 to 1.72) but not in patients with longer disease duration (for 5 to 10 years: OR, 1.07; 95% CI, 0.75 to 1.52; for = 10 years: OR, 0.92; 95% CI, 0.65 to 1.28). Conclusions: Early diagnosis is associated with no functional disability, especially in patients with shorter disease duration.en_US
dc.description.sponsorshipThis study was supported by the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020). The authors wish to acknowledge the assistance of the following investigators who enrolled patients in KORONA: Joong Kyoung Ahn (Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul), Sung Jae Choi (Korea University Ansan Hospital, Ansan), Minyoung Her (Inje University Busan Paik Hospital, Busan), Chung- Il Joung (Konyang University Hospital, Daejeon), Young Mo Kang (Kyungpook National University Hospital, Daegu), Dong- Yook Kim (Inje University Busan Paik Hospital, Busan), Hae- Rim Kim (Konkuk University Medical Center, Seoul), Hyoun Ah Kim (Ajou University Hospital, Suwon), Choong Ki Lee (Yeungnam University Medical Center, Daegu), Sang- Hoon Lee (Kyung Hee University Hospital at Gangdong, Seoul), Seong- Su Nah (Soon Chun Hyang University Cheonan Hospital, Cheonan), Sung- Hoon Park (Catholic University of Daegu School of Medicine, Daegu), Dong Hyuk Sheen (Eulji University Hospital, Daejeon), Gwan Gyu Song (Korea University Guro Hospital, Seoul), Chang- Hee Suh (Ajou University Hospital, Suwon), and Yoo Wan- Hee (Chonbuk National University Hospital, Jeonju).en_US
dc.language.isoenen_US
dc.publisherKOREAN ASSOC INTERNAL MEDICINEen_US
dc.subjectEarly diagnosisen_US
dc.subjectDisabilityen_US
dc.subjectArthritisen_US
dc.subjectrheumatoiden_US
dc.subjectHealth assessment questionnairesen_US
dc.titleImpact of early diagnosis on functional disability in rheumatoid arthritis.en_US
dc.typeArticleen_US
dc.identifier.doi10.3904/kjim.2015.364-
dc.relation.page1-9-
dc.relation.journalKOREAN JOURNAL OF INTERNAL MEDICINE-
dc.contributor.googleauthorKim, Dam-
dc.contributor.googleauthorChoi, Chan-Bum-
dc.contributor.googleauthorLee, Jiyoung-
dc.contributor.googleauthorCho, Soo-Kyung-
dc.contributor.googleauthorWon, Soyoung-
dc.contributor.googleauthorBang, So-Young-
dc.contributor.googleauthorCha, Hoon-Suk-
dc.contributor.googleauthorChoe, Jung-Yoon-
dc.contributor.googleauthorChung, Won Tae-
dc.contributor.googleauthorHong, Seung-Jae-
dc.relation.code2016007062-
dc.sector.campusS-
dc.sector.daehakINDUSTRY-UNIVERSITY COOPERATION FOUNDATION[S]-
dc.sector.departmentRESEARCH INSTITUTE-
dc.identifier.piddamkim-


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