67 0

Regioselective succinylation and gelation behavior of glycol chitosan

Title
Regioselective succinylation and gelation behavior of glycol chitosan
Author
조용우
Keywords
chitosan; biopolymers; regioselectivity; succinylation; gelation; SELF-ASSEMBLED NANOPARTICLES; DRUG-DELIVERY; ACID; WATER; CARRIER; DNA
Issue Date
2008-02
Publisher
POLYMER SOC KOREA
Citation
MACROMOLECULAR RESEARCH, v. 16, No. 1, Page. 57-61
Abstract
Chitosan is normally acylated and subsequently conjugated with drugs for biomedical applications. This study examined the relationship between the succinylation and gelation behaviors of glycol chitosan. Glycol chitosan was acylated with succinic anhydride under a wide variety of reaction conditions, such as different molar ratios of succinic anhydride to glucosamine, different methanol content in the reaction media, and different reaction temperatures. Among these reaction parameters, the methanol content in the solvent played an important role in determining the regioseletive succinylating site. N-succinylation and N-N cross-linking occurred regardless of the reaction conditions. However, O-succinylation was observed under specific conditions, i.e. a methanol content > 0.6 (v/v) and a reaction temperature > 25 °C. O-succinylation accelerated the N-O cross-linking of glycol chitosan, and led to gelation. The N-succinylated glycol chitosans were water-soluble, whereas the N- and O-succinylated glycol chitosans formed a gel. These physico-chemical structural differences in the succinylated glycol chitosans would definitely influence subsequent drug-conjugation reactions and consequently the drug loading and release kinetics.
URI
https://link.springer.com/article/10.1007/BF03218961https://repository.hanyang.ac.kr/handle/20.500.11754/76858
ISSN
1598-5032
DOI
10.1007/BF03218961
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE