Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오기욱 | - |
dc.date.accessioned | 2018-10-15T00:53:34Z | - |
dc.date.available | 2018-10-15T00:53:34Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | JOURNAL OF THE NEUROLOGICAL SCIENCES, v. 367, Page. 83-88 | en_US |
dc.identifier.issn | 0022-510X | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0022510X16302520?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/76508 | - |
dc.description.abstract | Objective: This study aimed to measure serum 25-hydroxyvitamin D [25(OH)D] concentrations, bone mineral density (BMD), and the parameters of bone metabolism in amyotrophic lateral sclerosis (ALS) patients, and their correlation with survival. Methods: We retrospectively analysed data of 100 ALS patients who consecutively visited a single referral ALS clinic between January and December 2011. Sex; age and site of symptom onset; and death were recorded. Serum 25(OH)D concentration was dichotomized as b10 ng/ml and ≥10 ng/ml. Results: There was absent relationship between serum 25(OH)D and concentration of bone turnover parameters or between 25(OH)D and BMD. According to the results of the Kaplan–Meier analysis with log-rank test, the survival rates of patients without (≥10 ng/ml) and of those with severe vitamin D deficiency (b 10ng/ml) were not significantly different. Cox regression analysis showed that a poor prognosis was most correlated with older age at onset and bulbar onset after adjustment for all the clinical factors. Conclusions: In conclusion, vitamin D levels were not correlated to other bone markers and survival in a clinic population of ALS patients. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Health Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (HI12C0135). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Amyotrophic lateral sclerosis | en_US |
dc.subject | Vitamin D | en_US |
dc.subject | Bone density | en_US |
dc.subject | Survival | en_US |
dc.title | Vitamin D levels are not predictors of survival in a clinic population of patients with ALS | en_US |
dc.type | Article | en_US |
dc.relation.volume | 367 | - |
dc.identifier.doi | 10.1016/j.jns.2016.05.007 | - |
dc.relation.page | 83-88 | - |
dc.relation.journal | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.contributor.googleauthor | Yang, Jiwon | - |
dc.contributor.googleauthor | Park, Jin-Seok | - |
dc.contributor.googleauthor | Oh, Ki-Wook | - |
dc.contributor.googleauthor | Park, Hyeon-Mi | - |
dc.contributor.googleauthor | Kim, Seung Hyun | - |
dc.relation.code | 2016001631 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kiwook-oh | - |
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