Vitamin D levels are not predictors of survival in a clinic population of patients with ALS
- Title
- Vitamin D levels are not predictors of survival in a clinic population of patients with ALS
- Author
- 오기욱
- Keywords
- Amyotrophic lateral sclerosis; Vitamin D; Bone density; Survival
- Issue Date
- 2016-08
- Publisher
- ELSEVIER SCIENCE BV
- Citation
- JOURNAL OF THE NEUROLOGICAL SCIENCES, v. 367, Page. 83-88
- Abstract
- Objective: This study aimed to measure serum 25-hydroxyvitamin D [25(OH)D] concentrations, bone mineral density (BMD), and the parameters of bone metabolism in amyotrophic lateral sclerosis (ALS) patients, and their correlation with survival.
Methods: We retrospectively analysed data of 100 ALS patients who consecutively visited a single referral ALS clinic between January and December 2011. Sex; age and site of symptom onset; and death were recorded. Serum 25(OH)D concentration was dichotomized as b10 ng/ml and ≥10 ng/ml.
Results: There was absent relationship between serum 25(OH)D and concentration of bone turnover parameters or between 25(OH)D and BMD. According to the results of the Kaplan–Meier analysis with log-rank test, the survival rates of patients without (≥10 ng/ml) and of those with severe vitamin D deficiency (b 10ng/ml) were not significantly different. Cox regression analysis showed that a poor prognosis was most correlated with older age at onset and bulbar onset after adjustment for all the clinical factors.
Conclusions: In conclusion, vitamin D levels were not correlated to other bone markers and survival in a clinic population of ALS patients.
- URI
- https://www.sciencedirect.com/science/article/pii/S0022510X16302520?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/76508
- ISSN
- 0022-510X
- DOI
- 10.1016/j.jns.2016.05.007
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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