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Vitamin D levels are not predictors of survival in a clinic population of patients with ALS

Title
Vitamin D levels are not predictors of survival in a clinic population of patients with ALS
Author
오기욱
Keywords
Amyotrophic lateral sclerosis; Vitamin D; Bone density; Survival
Issue Date
2016-08
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF THE NEUROLOGICAL SCIENCES, v. 367, Page. 83-88
Abstract
Objective: This study aimed to measure serum 25-hydroxyvitamin D [25(OH)D] concentrations, bone mineral density (BMD), and the parameters of bone metabolism in amyotrophic lateral sclerosis (ALS) patients, and their correlation with survival. Methods: We retrospectively analysed data of 100 ALS patients who consecutively visited a single referral ALS clinic between January and December 2011. Sex; age and site of symptom onset; and death were recorded. Serum 25(OH)D concentration was dichotomized as b10 ng/ml and ≥10 ng/ml. Results: There was absent relationship between serum 25(OH)D and concentration of bone turnover parameters or between 25(OH)D and BMD. According to the results of the Kaplan–Meier analysis with log-rank test, the survival rates of patients without (≥10 ng/ml) and of those with severe vitamin D deficiency (b 10ng/ml) were not significantly different. Cox regression analysis showed that a poor prognosis was most correlated with older age at onset and bulbar onset after adjustment for all the clinical factors. Conclusions: In conclusion, vitamin D levels were not correlated to other bone markers and survival in a clinic population of ALS patients.
URI
https://www.sciencedirect.com/science/article/pii/S0022510X16302520?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/76508
ISSN
0022-510X
DOI
10.1016/j.jns.2016.05.007
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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