Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2018-10-12T07:50:52Z | - |
dc.date.available | 2018-10-12T07:50:52Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | BIOMATERIALS, v. 97, Page. 164-175 | en_US |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0142961216301363?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/76500 | - |
dc.description.abstract | In consensus, myocardial infarction (MI) is defined as irreversible cell death secondary to prolonged ischemia in heart. The aim of our study was to evaluate the therapeutic potential of anti-fibrotic human Relaxin-expressing plasmid DNA with hypoxia response element (HRE) 12 copies (HR1) delivered by a dendrimer type PAM-ABP polymer G0 (HR1/G0) after MI on functional, hemodynamic, geometric, and cardiac extracellular matrix (ECM) remodeling in rats. HR1/G0 demonstrated significantly improved LV systolic function, hemodynamic parameters, and geometry on 1 wk and 4 wks after MI in rats, compared with I/R group. The resolution of regional wall motional abnormalities and the increased blood flow of infarct-related coronary artery supported functional improvements of HR1/G0. Furthermore, HR1/G0 polyplex showed favorable post-infarct cardiac ECM remodeling reflected on the favorable cardiac ECM compositions. Overall, this is the first study, which presented an advanced platform for the gene therapy that reverses adverse cardiac remodeling after MI with a HR1 gene delivered by a bioreducible dendrimer polymer in the cardiac ECM. (C) 2016 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by grants from the National Research Foundation of Korea (2015R1A2A1A13027811 and 2013M3A9D3045879; Dr. C-O Yun) and the University of Utah Small Animal Ultrasound Core Facility in addition to the NIH National Center for Research through Award Number 1S10RR027506-01A01. The authors declare no competing financial interests. Hadi Javan, Christin Schaaf, and Kevin Whitehead M.D. guided and provided advices for TTE. Jaesung Kim and Il-Kyu Choi gave advices to construct the pDNA modification. Kihoon Nam synthesized our bioreducible polymers. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.subject | Relaxin gene therapy | en_US |
dc.subject | Myocardial infarction | en_US |
dc.subject | Bioreducible polymer | en_US |
dc.subject | Dendrimer | en_US |
dc.subject | Cardiac extracellular matrix (ECM) | en_US |
dc.subject | Post-infarct remodeling | en_US |
dc.subject | Infarct-related coronary artery | en_US |
dc.title | Human relaxin gene expression delivered by bioreducible dendrimer polymer for post-infarct cardiac remodeling in rats | en_US |
dc.type | Article | en_US |
dc.relation.volume | 97 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2016.04.025 | - |
dc.relation.page | 164-175 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.contributor.googleauthor | Lee, Young Sook | - |
dc.contributor.googleauthor | Choi, Joung-Woo | - |
dc.contributor.googleauthor | Oh, Jung-Eun | - |
dc.contributor.googleauthor | Yun, Chae-Ok | - |
dc.contributor.googleauthor | Kim, Sung Wan | - |
dc.relation.code | 2016001577 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | chaeok | - |
dc.identifier.orcid | http://orcid.org/0000-0002-9466-4531 | - |
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