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dc.contributor.author이수재-
dc.date.accessioned2018-09-27T06:16:03Z-
dc.date.available2018-09-27T06:16:03Z-
dc.date.issued2016-08-
dc.identifier.citationONCOTARGET, v. 7, NO. 33, Page. 53430-53442en_US
dc.identifier.issn1949-2553-
dc.identifier.urihttp://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=10802&path[]=34200-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/76196-
dc.description.abstractEpithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in fractionally-irradiated tumors as compared to non-irradiated tumors that are accompanied by an EMT. Moreover, we uncovered the mechanism of Notch-driven EMT, in which Notch enhanced EMT through IL-6/JAK/STAT3 signaling axis in mammary tumor cells. Collectively, we present converging evidence from our studies that Notch2 is a critical mediator of radiation-induced EMT and responsible for induced malignant tumor growth.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation and Ministry of Science, ICT and Future Planning, Korean government (NRF-2015M2A2A7A01044998 and NRF-2015M2A2A7061626).en_US
dc.language.isoenen_US
dc.publisherIMPACT JOURNALS LLCen_US
dc.subjectradiationen_US
dc.subjectEMTen_US
dc.subjectNotch signalingen_US
dc.subjectinterleukin-6en_US
dc.subjectbreast canceren_US
dc.titleRadiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast canceren_US
dc.typeArticleen_US
dc.relation.no33-
dc.relation.volume7-
dc.identifier.doi10.18632/oncotarget.10802-
dc.relation.page53430-53442-
dc.relation.journalONCOTARGET-
dc.contributor.googleauthorKim, Rae-Kwon-
dc.contributor.googleauthorKaushik, Neha-
dc.contributor.googleauthorSuh, Yongjoon-
dc.contributor.googleauthorYoo, Ki-Chun-
dc.contributor.googleauthorCui, Yan-Hong-
dc.contributor.googleauthorKim, Min-Jung-
dc.contributor.googleauthorLee, Hae-June-
dc.contributor.googleauthorKim, In-Gyu-
dc.contributor.googleauthorLee, Su-Jae-
dc.relation.code2016010107-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidsj0420-
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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