Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한중수 | - |
dc.date.accessioned | 2018-09-27T02:09:11Z | - |
dc.date.available | 2018-09-27T02:09:11Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 6, Page. 31984-31992 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/srep31984 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/76171 | - |
dc.description.abstract | Single-Si-nanowire (NW)-based DNA sensors have been recently developed, but their sensitivity is very limited because of high noise signals, originating from small source-drain current of the single Si NW. Here, we demonstrate that chemical-vapor-deposition-grown large-scale graphene/surfacemodified vertical-Si-NW-arrays junctions can be utilized as diode-type biosensors for highly-sensitive and -selective detection of specific oligonucleotides. For this, a twenty-seven-base-long synthetic oligonucleotide, which is a fragment of human DENND2D promoter sequence, is first decorated as a probe on the surface of vertical Si-NW arrays, and then the complementary oligonucleotide is hybridized to the probe. This hybridization gives rise to a doping effect on the surface of Si NWs, resulting in the increase of the current in the biosensor. The current of the biosensor increases from 19 to 120% as the concentration of the target DNA varies from 0.1 to 500 nM. In contrast, such biosensing does not come into play by the use of the oligonucleotide with incompatible or mismatched sequences. Similar results are observed from photoluminescence microscopic images and spectra. The biosensors show very-uniform current changes with standard deviations ranging similar to 1 to similar to 10% by ten-times endurance tests. These results are very promising for their applications in accurate, selective, and stable biosensing. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the ministry of Science, ICT & Future Planning (Grant No. 2011-0017373). | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | ENERGY-TRANSFER | en_US |
dc.subject | COVALENT IMMOBILIZATION | en_US |
dc.subject | SILICON PARTICLES | en_US |
dc.subject | TRANSISTOR | en_US |
dc.subject | NANOSENSORS | en_US |
dc.subject | POLYMERS | en_US |
dc.subject | SEQUENCE | en_US |
dc.subject | SENSORS | en_US |
dc.subject | PROTEIN | en_US |
dc.title | Precise and selective sensing of DNA-DNA hybridization by graphene/Si-nanowires diode-type biosensors | en_US |
dc.type | Article | en_US |
dc.relation.volume | 6 | - |
dc.identifier.doi | 10.1038/srep31984 | - |
dc.relation.page | 31984-31992 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Kim, Jungkil | - |
dc.contributor.googleauthor | Park, Shin-Young | - |
dc.contributor.googleauthor | Kim, Sung | - |
dc.contributor.googleauthor | Lee, Dae Hun | - |
dc.contributor.googleauthor | Kim, Ju Hwan | - |
dc.contributor.googleauthor | Kim, Jong Min | - |
dc.contributor.googleauthor | Kang, Hee | - |
dc.contributor.googleauthor | Han, Joong-Soo | - |
dc.contributor.googleauthor | Park, Jun Woo | - |
dc.contributor.googleauthor | Lee, Hosun | - |
dc.contributor.googleauthor | Choi, Suk-Ho | - |
dc.relation.code | 2016012537 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jshan | - |
dc.identifier.orcid | http://orcid.org/0000-0002-0875-6158 | - |
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