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dc.contributor.author김선정-
dc.date.accessioned2018-09-04T09:33:25Z-
dc.date.available2018-09-04T09:33:25Z-
dc.date.issued2011-08-
dc.identifier.citationMolecules and cells, 2011, 32(2), P.153-160en_US
dc.identifier.issn1016-8478-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs10059-011-1019-1-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/74869-
dc.description.abstractThe interstitial cells of Cajal (ICCs) are pacemakers in the gastrointestinal tract and transient receptor potential melastatin type 7 (TRPM7) is a candidate for pacemaker channels. The effect of the 5-lipoxygenase (5-LOX) inhibitors NDGA, AA861, MK886 and zileuton on pacemaking activity of ICCs was examined using the whole cell patch clamp technique. NDGA and AA861 decreased the amplitude of pacemaker potentials in ICC clusters, but the resting membrane potentials displayed little change, respectively. Also, perfusing NDGA and AA861 into the bath reduced both inward current and outward current in TRPM7-like current in single ICC, respectively. But, they had no effects on Ca(2+) activated Cl(-) currents. The 5-LOX inhibitors MK886 and zileuton were, however, ineffective in pacemaker potentials in ICC clusters and in TRPM7-like current in single ICC, respectively. A specific TRPC3 inhibitor, pyrazole compound (Pyr3), and a specific TRPM4 inhibitor, 9-phenanthrol, had no effects in pacemaker potentials in ICC clusters and in TRPM7-like current in single ICC. These results suggest that, among the tested 5-LOX inhibitors, NDGA and AA861 modulate the pacemaker activities of the ICCs, and that the TRPM7 channel can affect intestinal motility.en_US
dc.language.isoenen_US
dc.publisherKorean SOC Molecular & Cellular Biologyen_US
dc.subject5-lipoxygenase inhibitoren_US
dc.subjectinterstitial cells of Cajalen_US
dc.subjectpacemakeren_US
dc.subjectTRPM7en_US
dc.titleEffects of transient receptor potential channel blockers on pacemaker activity in interstitial cells of Cajal from mouse small intestineen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume32-
dc.identifier.doi10.1007/s10059-011-1019-1-
dc.relation.page153-160-
dc.relation.journalMOLECULES AND CELLS-
dc.contributor.googleauthorKim, Byung Joo-
dc.contributor.googleauthorNam, Joo Hyun-
dc.contributor.googleauthorKim, Seon Jeong-
dc.contributor.googleauthor김병주-
dc.contributor.googleauthor남주현-
dc.contributor.googleauthor김선정-
dc.relation.code2011206841-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING-
dc.identifier.pidsjk-
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COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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