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Association between trabecular bone score and risk factors for fractures in Korean female patients with rheumatoid arthritis

Title
Association between trabecular bone score and risk factors for fractures in Korean female patients with rheumatoid arthritis
Author
김담
Keywords
Arthritis; Bone; Bone density; Fractures; Rheumatoid; Risk assessment; Trabecular bone score
Issue Date
2016-07
Publisher
SPRINGER
Citation
MODERN RHEUMATOLOGY, v. 26, NO 4, Page. 540-545
Abstract
Objective: To identify the association between trabecular bone score (TBS) and other known risk factors for fractures in rheumatoid arthritis (RA) patients.Methods: One hundred female RA patients aged50 years were enrolled. The following risk factors for fracture were selected: prevalent vertebral fracture (VF), bone mineral density (BMD), TBS, and 10-year probability of major osteoporotic fracture by FRAX (R) (MOF-FRAX scores). The associations between risk factors were identified, and accuracy of TBS, BMD, and FRAX scores to detect the prevalent VF, the strongest risk factor for future fracture, were assessed.Results: Twenty-six patients were revealed to have moderate to severe VFs. There was a modest negative correlation between MOF-FRAX score and TBS (r=-0.367, p<0.01), while there was no correlation between MOF-FRAX score and L-spine BMD (r=-0.050, p=0.62). The areas under curves (AUCs) were 0.818, 0.683, and 0.518 for the MOF-FRAX score, TBS, and L-spine BMD, respectively. Among patients with glucocorticoids (GC) use (n=57), AUCs were 0.762, 0.758, and 0.448 for their MOF-FRAX score, TBS, and L-spine BMD, respectively.Conclusions: TBS showed better correlation with MOF-FRAX score than BMD, and it was superior to BMD in identifying prevalent VFs in RA patients, especially who are in use of GCs.
URI
https://www.tandfonline.com/doi/full/10.3109/14397595.2015.1101212https://repository.hanyang.ac.kr/handle/20.500.11754/74387
ISSN
1439-7595; 1439-7609
DOI
10.3109/14397595.2015.1101212
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INDUSTRY-UNIVERSITY COOPERATION FOUNDATION[S](산학협력단) > ETC
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