Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | KAUSHIKNEHA | - |
dc.date.accessioned | 2018-08-06T00:46:12Z | - |
dc.date.available | 2018-08-06T00:46:12Z | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | ONCOTARGET, v. 7, NO 33, Page. 53430-53442 | en_US |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=10802&path[]=34200 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/74331 | - |
dc.description.abstract | Epithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in fractionally-irradiated tumors as compared to non-irradiated tumors that are accompanied by an EMT. Moreover, we uncovered the mechanism of Notch-driven EMT, in which Notch enhanced EMT through IL-6/JAK/STAT3 signaling axis in mammary tumor cells. Collectively, we present converging evidence from our studies that Notch2 is a critical mediator of radiation-induced EMT and responsible for induced malignant tumor growth. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation and Ministry of Science, ICT and Future Planning, Korean government (NRF-2015M2A2A7A01044998 and NRF-2015M2A2A7061626). | en_US |
dc.language.iso | en | en_US |
dc.publisher | IMPACT JOURNALS LLC | en_US |
dc.subject | radiation | en_US |
dc.subject | EMT | en_US |
dc.subject | Notch signaling | en_US |
dc.subject | interleukin-6 | en_US |
dc.subject | breast cancer | en_US |
dc.title | Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer | en_US |
dc.type | Article | en_US |
dc.relation.no | 33 | - |
dc.relation.volume | 7 | - |
dc.identifier.doi | 10.18632/oncotarget.10802 | - |
dc.relation.page | 53430-53442 | - |
dc.relation.journal | ONCOTARGET | - |
dc.contributor.googleauthor | Kim, Rae-Kwon | - |
dc.contributor.googleauthor | Kaushik, Neha | - |
dc.contributor.googleauthor | Suh, Yongjoon | - |
dc.contributor.googleauthor | Yoo, Ki-Chun | - |
dc.contributor.googleauthor | Cui, Yan-Hong | - |
dc.contributor.googleauthor | Kim, Min-Jung | - |
dc.contributor.googleauthor | Lee, Hae-June | - |
dc.contributor.googleauthor | Kim, In-Gyu | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.relation.code | 2016010107 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | THE RESEARCH INSTITUTE FOR NATURAL SCIENCES | - |
dc.identifier.pid | neha1987 | - |
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