Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민경환 | - |
dc.date.accessioned | 2018-07-26T01:37:28Z | - |
dc.date.available | 2018-07-26T01:37:28Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | Journal of Cutaneous Pathology, 2012, 39(6), p.582-595 | en_US |
dc.identifier.issn | 0303-6987 | - |
dc.identifier.issn | 1600-0560 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0560.2012.01903.x | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/73022 | - |
dc.description.abstract | The non-specific clinical findings and variable histopathologicalfeatures of cutaneous tuberculosis and non-tuberculous mycobacterialinfections often make it difficult to establish a diagnosis and initiateappropriate therapy. We investigated 25 patients diagnosed withmycobacterial infections of the skin in Hanyang University Hospitalbetween 2001 and 2011. Skin biopsy specimens were re-evaluated byvarious histopathological criteria and molecular studies. To identify themycobacteria, we performed staining for acid-fast bacilli and alsocompleted polymerase chain reaction analysis. The non-tuberculousmycobacterium species were identified by genetic sequencing offormalin-fixed, paraffin-embedded tissues. Immunocompromised statuswas more frequent in non-tuberculous mycobacterial infections than intuberculosis (p = 0.017) while disease duration was longer intuberculosis (p = 0.026). Microscopically, neutrophil infiltration,interstitial granuloma, small vessel proliferation and increased numbersof bacilli were found to be associated with non-tuberculousmycobacterial infections (all p < 0.05). In contrast, giant cells, plasmacells, tuberculoid granulomas and necrosis were associated withtuberculosis (all p < 0.05). There were no species-specifichistopathological findings in non-tuberculous mycobacterial infections.The significant histopathological differences between cutaneoustuberculous and non-tuberculous mycobacterial infections are helpfulin considering differential diagnoses. In addition, molecular techniquestogether with clinico-pathological findings may assist in makingaccurate diagnoses of cutaneous non-tuberculous mycobacterialinfections. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Society of Dermatopathology | en_US |
dc.subject | Mycobacterium tuberculosis | en_US |
dc.subject | non-tuberculousmycobacterium | en_US |
dc.subject | infection | en_US |
dc.title | Histopathological spectrum of cutaneous tuberculosis and nontuberculous mycobacterial infections | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1111/j.1600-0560.2012.01903.x | - |
dc.relation.journal | JOURNAL OF CUTANEOUS PATHOLOGY | - |
dc.contributor.googleauthor | Min, Kyueng-Whan | - |
dc.contributor.googleauthor | Ko, Joo-Yeon | - |
dc.contributor.googleauthor | Park, Chan-Kum | - |
dc.relation.code | 2012204948 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kyueng | - |
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