Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2018-07-25T08:32:40Z | - |
dc.date.available | 2018-07-25T08:32:40Z | - |
dc.date.issued | 2011-11 | - |
dc.identifier.citation | Wound Repair and Regeneration, 2011, 19(6), P.709-717 | en_US |
dc.identifier.issn | 1067-1927 | - |
dc.identifier.issn | 1524-475X | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-475X.2011.00733.x | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/72960 | - |
dc.description.abstract | Relaxin (RLX) has multiple vascular actions, including vasodilation and angiogenesis, which occur via induction of vascular endothelial growth factor (VEGF) expression. We generated a RLX-expressing (dE1-RGD/lacZ/RLX) adenovirus and investigated whether it enhances skin flap survival. Thirty Sprague-Dawley rats were divided into three groups: RLX-expressing adenovirus group, control virus group, and phosphate-buffered saline (PBS) group. Two days before surgery and immediately after flap elevation, the caudally based flap that was 3 9 cm in size was subdermally injected with the dE1-RGD/lacZ/RLX virus (10(7) PFU), dE1-RGD/lacZ virus (10(7) PFU), or PBS. The surviving area of the flap and the amount of blood flow were measured. On postoperative day 10, CD31-positive vessels and VEGF protein expression were examined. We observed a significant increase in the survival area of the flap in the RLX group. Doppler measurement also showed significantly increased blood flow immediately after the operation and on postoperative days 7 and 10. CD31-positive vessels and VEGF protein expression were significantly greater in the RLX group. Thus, administration of RLX-expressing adenovirus into elevated skin flaps increased VEGF expression, the number of capillaries, and blood flow to the flap, thereby improving skin flap survival. | en_US |
dc.description.sponsorship | This work was supported by a Faculty Research Grant from Yonsei University College of Medicine (6-2008-0138, Dr. DK Rah), the Ministry of Knowledge Economy (10030051, Dr. C-O Yun), and the Korea Science and Engineering Foundation (R15-2004-024-02001-0, 2009K001644, 2010-0029220, Dr. C-OYun). Il-Kyu Choi is a graduate student sponsored by KOSEF through the National Core Research Center for Nanomedical Technology, Yonsei University College of Medicine, Seoul, South Korea. Tae Jin Yun is a graduate student sponsored by the Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wound Healing Society | en_US |
dc.title | Augmentation of rat skin flap viability by relaxin-expressing adenovirus | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 19 | - |
dc.identifier.doi | 10.1111/j.1524-475X.2011.00733.x | - |
dc.relation.page | 709-717 | - |
dc.relation.journal | WOUND REPAIR AND REGENERATION | - |
dc.contributor.googleauthor | Lee, W. J. | - |
dc.contributor.googleauthor | Yun, C. O. | - |
dc.contributor.googleauthor | Yun, I. S. | - |
dc.contributor.googleauthor | Kim, Y. O. | - |
dc.contributor.googleauthor | Choi, I. K. | - |
dc.contributor.googleauthor | Yun, T. J. | - |
dc.contributor.googleauthor | Rah, D. K. | - |
dc.relation.code | 2011209898 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | chaeok | - |
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