Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 성윤경 | - |
dc.date.accessioned | 2018-07-25T04:54:29Z | - |
dc.date.available | 2018-07-25T04:54:29Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.citation | ARTHRITIS RESEARCH AND THERAPY,Vol.12, No.3 [2010],R115 | en_US |
dc.identifier.issn | 1478-6354 | - |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911908/ | - |
dc.identifier.uri | https://arthritis-research.biomedcentral.com/articles/10.1186/ar3051 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/72879 | - |
dc.description.abstract | Introduction: Anti-cyclic citrullinated peptide autoantibodies (anti-CCP) are the most specific serologic marker for rheumatoid arthritis (RA). Genetic polymorphisms in a citrullinating (or deiminating) enzyme, peptidyl arginine deiminase type IV (PADI4) have been reproducibly associated with RA susceptibility in several populations. We investigated whether PADI4 polymorphisms contribute to anti-CCP-negative as well as -positive RA, whether they influence disease severity (erosive joint status), and whether they interact with two major risk factors for RA, Human Leukocyte Antigen-DRB1 (HLA-DRB1) shared epitope (SE) alleles and smoking, depending on anti-CCP and erosive joint status.Methods: All 2,317 unrelated Korean subjects including 1,313 patients with RA and 1,004 unaffected controls were genotyped for three nonsynonymous (padi4_89, padi4_90, and padi4_92) and one synonymous (padi4_104) singlenucleotide polymorphisms (SNPs) in PADI4 and for HLA-DRB1 by direct DNA sequence analysis. Odds ratios (OR) were calculated by multivariate logistic regression. Interaction was evaluated by attributable proportions (AP), with 95% confidence intervals (CI).Results: A functional haplotype of the three fully correlated nonsynonymous SNPs in PADI4 was significantly associated with susceptibility to not only anti-CCP-positive (adjusted OR 1.73, 95% CI 1.34 to 2.23) but also -negative RA (adjusted OR 1.75, 95% CI 1.15 to 2.68). A strong association with both non-erosive (adjusted OR 1.62, 95% CI 1.29 to 2.05) and erosive RA (adjusted OR 1.62, 95% CI 1.14 to 2.31) was observed for PADI4 haplotype. Gene-gene interactions between the homozygous RA-risk PADI4 haplotype and SE alleles were significant in both anti-CCP-positive (AP 0.45, 95% CI 0.20 to 0.71) and -negative RA (AP 0.61, 95% CI 0.29 to 0.92). Theses interactions were also observed for both non-erosive (AP 0.48, 95% CI 0.25 to 0.72) and erosive RA (AP 0.46, 95% CI 0.14 to 0.78). In contrast, no interaction was observed between smoking and PADI4 polymorphisms.Conclusions: A haplotype of nonsynonymous SNPs in PADI4 contributes to development of RA regardless of anti-CCP or erosive joint status. The homozygous PADI4 haplotype contri bution is affected by gene-gene interactions with HLADRB1 SE alleles. | en_US |
dc.description.sponsorship | We are grateful to many research workers for assistance with sample preparation, data collection, and technical study. Dr. Bang's work was supported by a grant from the Korea Healthcare Technology R&D Project (A090706). Dr. Bae's work was supported by a grant from the Korea Healthcare Technology R&D Project (A084794 and A010252). Dr. Kang's work was supported by a grant from the Research Program for New Drug Target Discovery (M10748000231-08N4800-23110). | en_US |
dc.language.iso | en | en_US |
dc.publisher | BIOMED CENTRAL | en_US |
dc.title | Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 12 | - |
dc.identifier.doi | 10.1186/ar3051 | - |
dc.relation.page | 1-1 | - |
dc.relation.journal | ARTHRITIS RESEARCH & THERAPY | - |
dc.contributor.googleauthor | Sung, Yoon-Kyoung | - |
dc.contributor.googleauthor | Bang, So-Young | - |
dc.contributor.googleauthor | Han, Tae-Un | - |
dc.contributor.googleauthor | Choi, Chan-Bum | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Kang, Changwon | - |
dc.relation.code | 2011214612 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sungyk | - |
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