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dc.contributor.author이규용-
dc.date.accessioned2018-07-24T08:26:47Z-
dc.date.available2018-07-24T08:26:47Z-
dc.date.issued2011-01-
dc.identifier.citationEUROPEAN JOURNAL OF NEUROLOGY, 2011, 18(1), P.158-164en_US
dc.identifier.issn1351-5101-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/j.1468-1331.2010.03100.x/abstract?-
dc.description.abstractBackground and purpose:In this prospective study, we evaluated mutual relationships amongst microbleeds, matrix metalloproteinase-9 (MMP-9) and neurological deterioration in patients with their first acute lacunar stroke.Methods:Based on diffusion-weighted image findings, we recruited 206 patients with their first acute lacunar stroke. Those without a MRI scan were excluded. Small (a maximum lesion diameter of 15 mm) areas of subcortical gray and white matter with increased signals were considered as lacunar infarctions. GRE images were obtained within 24 h of the onset of stroke symptoms. Venous blood was sampled at base line (within 24 h). Clinical, biochemical, rheological and inflammatory parameters, neurological scales and free, active MMP-9 levels were compared between patients with and without microbleeds. Neurological deterioration was defined as an increase in more than two points on the National Institutes of Health Stroke Scale Score baseline 14 days after the onset of lacunar stroke.Results:Of the patients, 79 (38.3%) had microbleeds and 48 (23.3%) showed neurological deterioration. Free, active MMP-9 and C-reactive protein (CRP) levels were significantly increased amongst patients with microbleeds (P < 0.001 and P = 0.047, respectively). Existence of microbleeds (RR = 2.47, 95% CI = 1.25-3.83) and increased free, active MMP-9 (RR = 1.10 per 10 ng/ml, 95% CI = 1.03-1.19) were identified as independent risk factors for neurological deterioration after adjusting for potential confounders.Discussion:Increased levels of active MMP-9 and the existence of microbleeds might be useful in predicting the deterioration following an initial acute lacunar stroke.en_US
dc.description.sponsorshipThis work was supported by the Research fund of Hanyang University (HY-2007-T).en_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELL PUBLISHING, INCen_US
dc.subjectlacunar infarctionen_US
dc.subjectmatrix metalloproteinase-9en_US
dc.subjectmicrobleeden_US
dc.subjectprognosisen_US
dc.titleMicrobleeds and free active MMP-9 are independent risk factors for neurological deterioration in acute lacunar strokeen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume18-
dc.identifier.doi10.1111/j.1468-1331.2010.03100.x-
dc.relation.page158-164-
dc.relation.journalEUROPEAN JOURNAL OF NEUROLOGY-
dc.contributor.googleauthorKim, M. K.-
dc.contributor.googleauthorLee, K. -Y.-
dc.contributor.googleauthorKim, J.-
dc.contributor.googleauthorKim, H. -T.-
dc.contributor.googleauthorKim, S. H.-
dc.contributor.googleauthorChang, D. -I.-
dc.relation.code2011203034-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkylee-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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