515 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author최한곤-
dc.date.accessioned2018-07-24T05:06:20Z-
dc.date.available2018-07-24T05:06:20Z-
dc.date.issued2017-12-
dc.identifier.citationDRUG DELIVERY, v. 24, No. 1, Page. 1587-1597en_US
dc.identifier.issn1071-7544-
dc.identifier.issn1521-0464-
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/10717544.2017.1388452-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/72685-
dc.description.abstractStudies have shown that insertion of oleic acid into lipid bilayers can modulate the membrane properties of liposomes so as to improve their function as drug carriers. Considering that 2-hydroxyoleic acid (2OHOA), a potential antitumor agent currently undergoing clinical trials, is a derivative of oleic acid, we explored the possibility of developing 2OHOA-inserted liposomes as a multifunctional carrier of antitumor drugs in the present study. The insertion of 2OHOA into lipid bilayers was confirmed by surface charge determination and differential scanning calorimetry. 2OHOA insertion greatly decreased the order of dimyristoylphosphatidylcholine packing, produced a nanosized (˂100nm) dispersion, and improved the colloidal stability of liposomes during storage. Moreover, 2OHOA-inserted liposome forms exhibited greater growth inhibitory activity against cancer cells compared with free 2OHOA, and the growth-inhibitory activity of liposomal 2OHOA was selective for tumor cells. 2OHOA insertion greatly increased the liposome-incorporated concentration of hydrophobic model drugs, including mitoxantrone, paclitaxel, and all-trans retinoic acid (ATRA). The in vitro anticancer activity of ATRA-incorporated/2OHOA-inserted liposomes was significantly higher than that of ATRA-incorporated conventional liposomes. In a B16-F10 melanoma syngeneic mouse model, the tumor growth rate was significantly delayed in mice treated with ATRA-incorporated/2OHOA-inserted liposomes compared with that in the control group. Immunohistochemical analyses revealed that the enhanced antitumor activity of ATRA-incorporated/2OHOA-inserted liposomes was due, at least in part, to increased induction of apoptosis. Collectively, our findings indicate that 2OHOA-inserted liposomes exhibit multiple advantages as antitumor drug carriers, including the ability to simultaneously deliver two anticancer drugs - 2OHOA and incorporated drug - to the tumor tissue.en_US
dc.description.sponsorshipThis work was supported by a grant from the National Research Foundation of Korea (NRF) funded by the Korea government (MSIP) (No. 2015R1A2A2A01005783) and a grant (16173MFDS542) from Ministry of Food and Drug Safety in 2017.en_US
dc.language.isoen_USen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.subject2-Hydroxyoleic aciden_US
dc.subjectliposomeen_US
dc.subjectmultifunctionalen_US
dc.subjectcarrieren_US
dc.subjecthydrophobic drugen_US
dc.title2-Hydroxyoleic acid-inserted liposomes as a multifunctional carrier of anticancer drugsen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume24-
dc.identifier.doi10.1080/10717544.2017.1388452-
dc.relation.page1587-1597-
dc.relation.journalDRUG DELIVERY-
dc.contributor.googleauthorJang, Eun-Ji-
dc.contributor.googleauthorChoi, Woo Rim-
dc.contributor.googleauthorKim, Soo-Yeon-
dc.contributor.googleauthorHong, Soon-Seok-
dc.contributor.googleauthorRhee, Inmoo-
dc.contributor.googleauthorLee, Sang-Jin-
dc.contributor.googleauthorChoi, Sung Weon-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorLim, Soo-Jeong-
dc.relation.code2017005925-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE