Nanomedicine; Smart chemistry; Nanocarrier; Drug delivery
Issue Date
2017-07
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CONTROLLED RELEASE, v. 258, Page. 226-253
Abstract
This review focuses on the smart chemistry that has been utilized in developing polymer-based drug delivery systems over the past 10 years. We provide a comprehensive overview of the different functional moieties and reducible linkages exploited in these systems, and outline their design, synthesis, and application from a therapeutic efficacy viewpoint. Furthermore, we highlight the next generation nanomedicine strategies based on this novel chemistry.