Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진기 | - |
dc.date.accessioned | 2018-06-11T08:19:12Z | - |
dc.date.available | 2018-06-11T08:19:12Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.citation | CARBOHYDRATE POLYMERS, v. 159, Page. 39-47 | en_US |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0144861716313820 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/72000 | - |
dc.description.abstract | To improve the solubility and anticancer activity of albendazole (ABZ), chitosan (CS)-coated poly-dl-lactic-co-glycolic acid (PLGA) nanoparticles were developed. CS was used to coat ABZ-loaded PLGA nanoparticles to enhance both mucoadhesiveness and colloidal stability. CS-coated PLGA nanoparticles were prepared by suspending the nanoparticles in CS solution after solvent diffusion. The CS-coated PLGA nanoparticles were characterized, and ABZ release was studied in vitro from various formulations. The mucoadhesive properties and in vitro anticancer activities of CS-coated PLGA nanoparticles were investigated by measurement of zeta potentials and the MTT assay, respectively. Spherical nanoparticles below 500 nm in diameter were successfully prepared; the particle size distribution was narrow. Complete encapsulation of ABZ in CS-coated PLGA nanoparticles was confirmed by SEM, FTIR, DSC, and XRD. The particle sizes of CS-coated PLGA nanoparticles were in the range of 260-480 nm; the encapsulation efficiency was 43.4-54.6%; and the yield 58.5-67.8%. The zeta potential of CS-coated nanoparticles was above +27 mV and stability was maintained for 4 weeks. At pH 7.4, the in vitro release of ABZ from nanoparticles (P188-5) was 200-fold higher than that from untreated ABZ; this persisted for 12 h. Moreover, ABZ release from CS-coated PLGA nanoparticles (P188-CS0.5) was 1.5-fold higher than that from untreated ABZ at pH 1.2. Additionally, the ABZ-loaded CS-coated nanoparticles exhibited superior mucoadhesion and improved cytotoxicity. The results show that CS coating of PLGA nanoparticles may improve the anticancer effect and the mucoadhesive properties of ABZ-loaded nanoparticles. (C) 2016 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Korea government, MSIP (No. 2015R1A2A1A10051596). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.subject | MICROPARTICLES | en_US |
dc.subject | Mucoadhesion | en_US |
dc.subject | Albendazole | en_US |
dc.subject | PLGA Nanoparticle | en_US |
dc.subject | Chitosan | en_US |
dc.subject | Anticancer activity | en_US |
dc.subject | POLYSACCHARIDE | en_US |
dc.subject | SOLID LIPID NANOPARTICLES | en_US |
dc.subject | ORAL INSULIN DELIVERY | en_US |
dc.subject | DRUG-DELIVERY | en_US |
dc.subject | RELEASE | en_US |
dc.subject | BIOAVAILABILITY | en_US |
dc.subject | ABSORPTION | en_US |
dc.subject | POLYMERS | en_US |
dc.subject | PEPTIDE | en_US |
dc.title | Enhancing the in vitro anticancer activity of albendazole incorporated into chitosan-coated PLGA nanoparticles | en_US |
dc.type | Article | en_US |
dc.relation.volume | 159 | - |
dc.identifier.doi | 10.1016/j.carbpol.2016.12.009 | - |
dc.relation.page | 39-47 | - |
dc.relation.journal | CARBOHYDRATE POLYMERS | - |
dc.contributor.googleauthor | Kang, BS | - |
dc.contributor.googleauthor | Choi, JS | - |
dc.contributor.googleauthor | Lee, SE | - |
dc.contributor.googleauthor | Lee, JK | - |
dc.contributor.googleauthor | Kim, TH | - |
dc.contributor.googleauthor | Jang, WS | - |
dc.contributor.googleauthor | Tunsirikongkon, A | - |
dc.contributor.googleauthor | Kim, JK | - |
dc.contributor.googleauthor | Park, JS | - |
dc.relation.code | 2017002084 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | jinkikim | - |
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