Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers
- Title
- Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers
- Author
- 최한곤
- Keywords
- Zein nanoparticles; Bortezomib; Vorinostat; Prostate cancer; LIQUID-CRYSTALLINE NANOPARTICLES; GRAPHENE OXIDE; DRUG-DELIVERY; LIPID NANOPARTICLES; ANDROGEN RECEPTOR; BREAST-CANCER; CELLS; BORTEZOMIB; VORINOSTAT; RELEASE
- Issue Date
- 2017-03
- Publisher
- ELSEVIER SCIENCE BV
- Citation
- NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v. 13, No. 3, Page. 885-896
- Abstract
- The development of resistance and subsequent metastasis makes prostate cancer a leading cause of cancer-related death among men. Hence, nanoparticle-based combination chemotherapeutics could be a viable treatment strategy. Weaimed to prepare vorinostat (Vor) and bortezomib (Bor) combination-loaded zein nanoparticles (ZNP, ZNP/VB) for treating metastatic prostate cancers. Our results revealed the successful preparation of ZNP/VB with a small particle size (similar to 160 nm) and polydispersity index (similar to 0.20). Importantly, controlled and pH-dependent drug release profiles were observed. ZNP/VB exhibited high uptake in different prostate cancer cells and, thereby, exhibited higher cytotoxicity and apoptosis. Additionally, the enhanced anti-migration effect of and induction of pro-apoptotic proteins by ZNP/VB suggest its potential effectiveness in cancer treatment. ZNP/VB showed enhanced in vivo antitumor effects compared to that observed for each free drug and their combination, with minimal toxicity. Taken together, ZNP/VB could be a potential formulation for the effective treatment of metastatic prostate cancers. (C) 2016 Elsevier Inc. All rights reserved.
- URI
- https://www.ncbi.nlm.nih.gov/pubmed/27993720https://repository.hanyang.ac.kr/handle/20.500.11754/71849
- ISSN
- 1549-9634; 1549-9642
- DOI
- 10.1016/j.nano.2016.12.010
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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