Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 염종훈 | - |
dc.date.accessioned | 2018-05-30T00:47:59Z | - |
dc.date.available | 2018-05-30T00:47:59Z | - |
dc.date.issued | 2016-06 | - |
dc.identifier.citation | Anesthesia and Pain Medicine, v. 11, NO 3, Page. 255-259 | en_US |
dc.identifier.issn | 1975-5171 | - |
dc.identifier.issn | 2383-7977 | - |
dc.identifier.uri | http://www.anesth-pain-med.org/journal/view.html?doi=10.17085/apm.2016.11.3.255 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/71672 | - |
dc.description.abstract | Background: For many drugs, dosing scalars such as ideal body weight (IBW) and lean body mass are recommended over the use of total body weight (TBW) during weight-based dose calculations. Doses based on TBW are frequently used, and this may cause under- or over-dosing. Because dexmedetomidine (DEX) overdosing could increase the incidence of side effects, and spinal anesthesia may increase sensitivity to a sedative agent, determining an appropriate dose is critical. Methods: Eighty patients were randomly divided into 2 groups, the IBW and TBW groups. Patients received a loading dose of DEX 1 g/kg IBW or TBW for 10 min, followed by a continuous infusion at 0.5 g/kg/h IBW or TBW after the induction of spinal anesthesia. The patients’ vital signs, bispectral index (BIS), peripheral capillary oxygen saturation, time to reach a BIS of 80, airway obstruction score, and coughing were monitored and recorded at 0, 10, 30, and 50 min after the start of the loading dose injection. Results: The changes in BIS, airway obstruction score, the incidence of side effects, and time to reach a BIS of 80 did not show statistically significant differences between the two groups. However, airway obstruction and/or coughing occurred in both groups, and the average BIS in both groups was lower than the target BIS of 60–80 at 30 and 50 min. Conclusions: A loading dose of DEX 1 g/kg for 10 min, and a maintenance dose of DEX 0.5 g/kg/h of either IBW or TBW, may induce excessive sedation, airway obstruction, and/or coughing under spinal anesthesia. | en_US |
dc.language.iso | en | en_US |
dc.publisher | 대한마취통증의학회 | en_US |
dc.subject | Bispectral index monitor | en_US |
dc.subject | Dexmedetomidine | en_US |
dc.subject | Ideal body weight | en_US |
dc.subject | Spinal anesthesia | en_US |
dc.title | A loading dose of 1 μg/kg and maintenance dose of 0.5 μg/kg/h of dexmedetomidine for sedation under spinal anesthesia may induce excessive sedation and airway obstruction | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 11 | - |
dc.identifier.doi | https://doi.org/10.17085/apm.2016.11.3.255 | - |
dc.relation.page | 255-259 | - |
dc.relation.journal | Anesthesia and Pain Medicine | - |
dc.contributor.googleauthor | Yeom, Jong Hoon | - |
dc.contributor.googleauthor | Oh, Mi Kyung | - |
dc.contributor.googleauthor | Ahn, Dae-woong | - |
dc.contributor.googleauthor | Park, Soo In | - |
dc.relation.code | 2016018945 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | yeomjh | - |
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