Thermo-responsive human α-elastin self-assembled nanoparticles for protein delivery
- Title
- Thermo-responsive human α-elastin self-assembled nanoparticles for protein delivery
- Author
- 최지숙
- Keywords
- Human alpha-elastin; Thermo-responsive; Self-assembly; Nanoparticles; PEGylation; Protein delivery system; HUMAN TROPOELASTIN; CONTROLLED-RELEASE; ADIPOSE-TISSUE; DRUG-DELIVERY; INSULIN; MICROSPHERES; COACERVATION; BIOMATERIALS; GLUCOSE; PLGA
- Issue Date
- 2017-01
- Publisher
- Elsevier BV
- Citation
- Colloids and Surfaces B: Biointerfaces, v. 149, Page. 122-129
- Abstract
- Self-assembled nanoparticles based on PEGylated human α-elastin were prepared as a potential vehicle for sustained protein delivery. The α-elastin was extracted from human adipose tissue and modified with methoxypolyethyleneglycol (mPEG) to control particle size and enhance the colloidal stability. The PEGylated human α-elastin showed sol-to-particle transition with a lower critical solution temperature (LCST) of 25 °C–40 °C in aqueous media. The PEGylated human α-elastin nanoparticles (PhENPs) showed a narrow size distribution with an average diameter of 330 ± 33 nm and were able to encapsulate significant amounts of insulin and bovine serum albumin (BSA) upon simple mixing at low temperature in water and subsequent heating to physiological temperature. The release profiles of insulin and BSA showed sustained release for 72 h. Overall, the thermo-responsive self-assembled PhENPs provide a useful tool for a range of protein delivery and tissue engineering applications.
- URI
- https://www.sciencedirect.com/science/article/pii/S0927776516307160https://repository.hanyang.ac.kr/handle/20.500.11754/71653
- ISSN
- 0927-7765; 1873-4367
- DOI
- 10.1016/j.colsurfb.2016.10.012
- Appears in Collections:
- RESEARCH INSTITUTE[E](부설연구소) > INSTITUTE OF NANO SENSOR TECHNOLOGY(나노센서연구소) > Articles
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