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Thermo-responsive human α-elastin self-assembled nanoparticles for protein delivery

Title
Thermo-responsive human α-elastin self-assembled nanoparticles for protein delivery
Author
최지숙
Keywords
Human alpha-elastin; Thermo-responsive; Self-assembly; Nanoparticles; PEGylation; Protein delivery system; HUMAN TROPOELASTIN; CONTROLLED-RELEASE; ADIPOSE-TISSUE; DRUG-DELIVERY; INSULIN; MICROSPHERES; COACERVATION; BIOMATERIALS; GLUCOSE; PLGA
Issue Date
2017-01
Publisher
Elsevier BV
Citation
Colloids and Surfaces B: Biointerfaces, v. 149, Page. 122-129
Abstract
Self-assembled nanoparticles based on PEGylated human α-elastin were prepared as a potential vehicle for sustained protein delivery. The α-elastin was extracted from human adipose tissue and modified with methoxypolyethyleneglycol (mPEG) to control particle size and enhance the colloidal stability. The PEGylated human α-elastin showed sol-to-particle transition with a lower critical solution temperature (LCST) of 25 °C–40 °C in aqueous media. The PEGylated human α-elastin nanoparticles (PhENPs) showed a narrow size distribution with an average diameter of 330 ± 33 nm and were able to encapsulate significant amounts of insulin and bovine serum albumin (BSA) upon simple mixing at low temperature in water and subsequent heating to physiological temperature. The release profiles of insulin and BSA showed sustained release for 72 h. Overall, the thermo-responsive self-assembled PhENPs provide a useful tool for a range of protein delivery and tissue engineering applications.
URI
https://www.sciencedirect.com/science/article/pii/S0927776516307160https://repository.hanyang.ac.kr/handle/20.500.11754/71653
ISSN
0927-7765; 1873-4367
DOI
10.1016/j.colsurfb.2016.10.012
Appears in Collections:
RESEARCH INSTITUTE[E](부설연구소) > INSTITUTE OF NANO SENSOR TECHNOLOGY(나노센서연구소) > Articles
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