Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민선준 | - |
dc.date.accessioned | 2018-05-29T05:19:15Z | - |
dc.date.available | 2018-05-29T05:19:15Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 125, Page. 1172-1192 | en_US |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.issn | 1768-3254 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0223523416309552 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/71621 | - |
dc.description.abstract | In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP. We performed diverse mitochondrial functional assays to assess their ability to restore cells from A beta-induced toxicity in vitro and in vivo. Among tested compounds, compound 25 effectively improved cognitive function in animal models of AD. Given the excellent in vitro and in vivo activity and a favorable pharmacokinetic profile of compound 25, we believe that it can serve as a promising lead compound for a potential treatment option for AD. (C) 2016 Elsevier Masson SAS. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the National Research Council of Science & Technology (NST) grant by the Korea government (MSIP) (No. CRC-15-04-KIST) and KIST institutional program (2E26650). J.L. was supported by the Sungshin Women's University Research Grant of 2015-2-21-007. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | en_US |
dc.subject | Translocator protein | en_US |
dc.subject | TSPO | en_US |
dc.subject | Mitochondrial permeability transition pore | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Mitochondrial dysfunction | en_US |
dc.subject | A beta | en_US |
dc.subject | PERMEABILITY TRANSITION PORE | en_US |
dc.subject | AMYLOID-BETA | en_US |
dc.subject | CYCLOSPORINE-A | en_US |
dc.subject | CYCLOPHILIN-D | en_US |
dc.subject | BRAIN-INJURY | en_US |
dc.subject | MOUSE MODEL | en_US |
dc.subject | DYSFUNCTION | en_US |
dc.subject | INHIBITOR | en_US |
dc.subject | TSPO | en_US |
dc.subject | REPERFUSION | en_US |
dc.title | Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease | en_US |
dc.type | Article | en_US |
dc.relation.volume | 125 | - |
dc.identifier.doi | 10.1016/j.ejmech.2016.11.017 | - |
dc.relation.page | 1172-1192 | - |
dc.relation.journal | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.contributor.googleauthor | Kim, TaeHun | - |
dc.contributor.googleauthor | Yang, Ha Yun | - |
dc.contributor.googleauthor | Park, Beoung Gun | - |
dc.contributor.googleauthor | Jung, Seo Yun | - |
dc.contributor.googleauthor | Park, Jong-Hyun | - |
dc.contributor.googleauthor | Park, Ki Duk | - |
dc.contributor.googleauthor | Min, Sun-Joon | - |
dc.contributor.googleauthor | Tae, Jinsung | - |
dc.contributor.googleauthor | Yang, Hyejin | - |
dc.contributor.googleauthor | Cho, Suengmok | - |
dc.contributor.googleauthor | Cho, Sung Jin | - |
dc.contributor.googleauthor | Song, Hyundong | - |
dc.contributor.googleauthor | Mook-Jung, Inhee | - |
dc.contributor.googleauthor | Lee, Jiyoun | - |
dc.contributor.googleauthor | Pae, Ae Nim | - |
dc.relation.code | 2017000237 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING | - |
dc.identifier.pid | sjmin | - |
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