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dc.contributor.author최한곤-
dc.date.accessioned2018-05-29T04:48:25Z-
dc.date.available2018-05-29T04:48:25Z-
dc.date.issued2017-01-
dc.identifier.citationINTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 519, No. 1-2, Page. 11-21en_US
dc.identifier.issn0378-5173-
dc.identifier.issn1873-3476-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S037851731730011X-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/71610-
dc.description.abstractAlthough protein-bound paclitaxel (PTX, Abraxane (R)) has been established as a standard PTX-based therapy against multiple cancers, its clinical success is limited by unfavorable pharmacokinetics, suboptimal biodistribution, and acute toxicities. In the present study, we aimed to apply the principles of a layer-by-layer(LbL) technique to improve the poor colloidal stability and pharmacokinetic pattern of nanoparticle albumin-bound paclitaxel (nab-PTX). LbL-based nab-PTX was successfully fabricated by the alternate deposition of polyarginine (pARG) and poly(ethylene glycol)-block-poly(L-aspartic acid) (PEGb-PLD) onto an albumin conjugate. The presence of protective entanglement by polyamino acids prevented the dissociation of nab-PTX and improved its colloidal stability even at a 100-fold dilution. The combined effect of high nanoparticle internalization and controlled release of PTX from LbL-nab-PTX increased its cytotoxicity in MCF-7 and MDA-MB-231 breast cancer cells. LbL-nab-PTX consistently induced apoptosis in approximately 52% and 22% of MCF-7 and MDA-MB-231 cancer cells, respectively. LbL assembly of polypeptides effectively prevented exposure of PTX to the systemic environment and thereby inhibited drug-induced hemolysis. Most importantly, LbL assembly of polypeptides to nab-PTX effectively increased the blood circulation potential of PTX and improved therapeutic efficacy via a significantly higher area under the curve (AUC)(0-infinity). We report for the first time the application of LbL functional architectures for improving the systemic performance of nab-PTX with a view toward its clinical translation for cancer therapy. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2015R1A2A2A01004118, 2015R1A2A2A04004806).en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectAlbuminen_US
dc.subjectNanoparticleen_US
dc.subjectColloidal stabilityen_US
dc.subjectSystemic performanceen_US
dc.subjectBreast canceren_US
dc.subjectDRUG-DELIVERYen_US
dc.subjectANTITUMOR EFFICACYen_US
dc.subjectIN-VIVOen_US
dc.subjectMICELLESen_US
dc.subjectRELEASEen_US
dc.subjectDOXORUBICINen_US
dc.subjectCHITOSANen_US
dc.subjectCANCERen_US
dc.subjectIRINOTECANen_US
dc.subjectTAXANEen_US
dc.titleLayer-by-layer assembly of hierarchical nanoarchitectures to enhance the systemic performance of nanoparticle albumin-bound paclitaxelen_US
dc.typeArticleen_US
dc.relation.no1-2-
dc.relation.volume519-
dc.identifier.doi10.1016/j.ijpharm.2017.01.011-
dc.relation.page11-21-
dc.relation.journalINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.contributor.googleauthorRuttala, Hima Bindu-
dc.contributor.googleauthorRamasamy, Thiruganesh-
dc.contributor.googleauthorShin, Beom Soo-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorYong, Chul Soon-
dc.contributor.googleauthorKim, Jong Oh-
dc.relation.code2017002781-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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