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Incorporation of chemotherapeutic agent and photosensitizer in a low temperature-sensitive liposome for effective chemo-hyperthermic anticancer activity

Title
Incorporation of chemotherapeutic agent and photosensitizer in a low temperature-sensitive liposome for effective chemo-hyperthermic anticancer activity
Author
최한곤
Keywords
Docetaxel; indocyanine green; hyperthermia; low temperature-sensitive liposome; near-infrared irradiation; BREAST-CANCER CELLS; INDOCYANINE GREEN; DRUG-DELIVERY; IN-VIVO; THERMOSENSITIVE LIPOSOMES; CHOLESTERYL HEMISUCCINATE; PHOTODYNAMIC THERAPY; NANOPARTICLES; DOCETAXEL; PHOTOTHERAPY
Issue Date
2017-01
Publisher
TAYLOR & FRANCIS LTD
Citation
EXPERT OPINION ON DRUG DELIVERY, v. 14, No. 2, Page. 155-164
Abstract
Objectives: In this study, we combined chemo- and hyperthermia therapy in a low temperature-sensitive liposome (LTSL) for potential cancer treatment. Methods: Docetaxel (DOC) and indocyanine green (ICG) as a therapeutic agent and photosensitizer, respectively, were incorporated in a low temperature-sensitive liposome (LTSL/DI). Nanoparticles were evaluated for the physicochemical characterizations, in vitro uptake and cytotoxicity, and furthermore in vivo anticancer activity. Results: The particle size of LTSL/DI was 130.82.3nm, and its drug release profile was pH- and temperature-dependent, which are effective for tumor targeting. The in vitro anticancer activity of LTSL/DI was significantly enhanced compared with free DOC in SCC-7 and MCF-7 cell lines. Interestingly, near-infrared laser irradiation after the treatment resulted in better anticancer activity than in the non-irradiated condition. The in vivo tumor regression effect of LTSL/DI in combination with NIR irradiation was much greater compared with the control group in SCC-7 tumor-bearing mice. After intratumoral injection of LTSL/DI, local heat induced by NIR irradiation and the localized docetaxel burst release could completely ablate the tumor, and inhibit its recurrence. Conclusions: These results suggest LTSL/DI formulation as a potential therapeutic strategy with effectively localized anti-tumor activity and low risk of side effect to non-target organs.
URI
https://www.tandfonline.com/doi/abs/10.1080/17425247.2017.1266330https://repository.hanyang.ac.kr/handle/20.500.11754/71607
ISSN
1742-5247; 1744-7593
DOI
10.1080/17425247.2017.1266330
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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